Results 41 to 50 of about 575,882 (298)

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Ultra-High Prostate-Specific Antigen Level: A Potential Very-High-Risk Factor for Localized High-Risk Prostate Cancer

Cancers, 2023
To examine the impact of ultra-high iPSA levels of >50 ng/mL (uhPSA) after modern radiotherapy, we compared outcomes of 214 patients with uhPSA levels to 1161 other high-risk patients. Radiotherapy included brachytherapy ± external beam radiotherapy (EBRT) and EBRT alone (intensity-modulated radiotherapy or stereotactic body radiotherapy).
Hideya Yamazaki, Gen Suzuki, Koji Masui, Kei Yamada, Takashi Ueda, Takumi Shiraishi, Atsuko Fujihara, Takashi Kato, Yasutoshi Hashimoto, Haruumi Okabe   +9 more
openaire   +2 more sources

Predictors of remission from the ultra‐high risk state for psychosis [PDF]

Early Intervention in Psychiatry, 2020
AbstractAimA significant proportion of individuals at Ultra‐High Risk (UHR) for psychosis do not transition to manifest psychosis. Many non‐transitioning UHR individuals do, however, display poor long‐term outcomes such as persistence of attenuated psychotic symptoms.
Louise B. Glenthøj, Tina D. Kristensen, Christina Wenneberg, Carsten Hjorthøj, Merete Nordentoft   +4 more
openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Clinical profile, conversion rate, and suicidal thinking and behaviour in children and adolescents at ultra-high risk for psychosis: a theoretical perspective

Research in Psychotherapy, 2020
Over the past years there has been substantial growing interest in the prodromes of psychosis to identify individuals at risk for psychosis prior to their first psychotic episode.
Maria Pontillo, Maria Cristina Tata, Roberto Averna, Prisca Gargiullo, Silvia Guerrera, Stefano Vicari   +5 more
doaj   +1 more source

Ultra-high-risk choriocarcinoma with atraumatic splenic rupture: a rare case report

Journal of International Medical Research, 2021
Choriocarcinoma is a malignant tumor associated with early vascular invasion and a high mortality. Ultra-high-risk choriocarcinoma, which was proposed in the International Federation of Gynecology and Obstetrics cancer report of 2018, has a higher risk ...
Jun Zhang, Xinchun Bi, Qi Xin, Aihua Zhang   +3 more
doaj   +1 more source

A surface-based morphometry study of risk and resilience markers associated with supramarginal thickness in schizophrenia

European Psychiatry, 2021
Introduction Conventional structural neuroimaging methods can identify changes in cortical thickness but cannot relate these changes to specific cortical layers due to a lack of sensitivity.
A. Tomyshev, M. Omelchenko, V. Kaleda, I. Lebedeva   +3 more
doaj   +1 more source

Ultra-short echo time cardiovascular magnetic resonance of atherosclerotic carotid plaque. [PDF]

, 2010
BACKGROUND: Multi-contrast weighted cardiovascular magnetic resonance (CMR) allows detailed plaque characterisation and assessment of plaque vulnerability.
Boyle, JJ, Chan, CF, Firmin, DN, Gatehouse, P, Keenan, NG, Nielles-Vallespin, S, Pennell, DJ, Sheppard, MN   +7 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Case Report: First-Line Immune Checkpoint Inhibitor Plus Chemotherapy for Oral Metastasis in a Patient with Ultra High-Risk Gestational Choriocarcinoma

Cancer Management and Research, 2022
Yu Chen,1,* Haiyan Ye,2,* Jiming Tang,3 Yihan Weng,4 Jie Zhang,5 Jianhua Liu4 1Department of Pathology, Guangdong Provincial People’s Hospital, Second Clinical Medical College of Southern Medical University, Guangdong Academy of Medical Sciences,
Chen Y, Ye H, Tang J, Weng Y, Zhang J, Liu J   +5 more
doaj