Results 181 to 190 of about 70,242 (336)

An Alternative Gene Editing Strategy Using a Single AAV Vector. [PDF]

Bio Protoc
Moffa JC, Kalyanaraman V, Copits BA.
europepmc   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Evaluating Outer Membrane Vesicle Isolation Techniques for <i>Borrelia burgdorferi</i> and Their Impact on Vesicle Composition, Gene Expression Profile and Uptake. [PDF]

Antibiotics (Basel)
Jathan J, Pandya JM, Jain M, Kaithalapuram T, Cherukuri D, Sapi E.   +5 more
europepmc   +1 more source

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source

Protocol for isolating patient-derived ascites cells and extracellular vesicles from gastric cancer peritoneal metastases. [PDF]

STAR Protoc
Fan Y, Vykoukal JV, Song S, Pizzi MP, Zou G, Yoshimura K, Jin J, Katayama H, Calin GA, Waters RE, Gan Q, Wang L, Hanash S, Dhar SS, Ajani JA.   +14 more
europepmc   +1 more source

Protocol for the isolation of human neutrophil-derived extracellular vesicles for characterization and functional experimentation. [PDF]

STAR Protoc
Richter R, Sari E, Stacks D, Lewis C, Smith J, Xu N, Langster T, Finley D, Margaroli C, Genschmer KR.   +9 more
europepmc   +1 more source

Proteomic Characterization of Spinal Cord Myelin in the Mouse. [PDF]

ASN Neuro
Schmitt O, Kaddatz H, Mikkat S, Kipp M, Schümann A, Joost S.   +5 more
europepmc   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

Labeling, isolation and characterization of cell-type-specific exosomes derived from mouse skin tissue. [PDF]

Nat Protoc
Yadav A, Sharma A, Moulick M, Gavande PV, Nandy A, Xuan Y, Sen CK, Ghatak S.   +7 more
europepmc   +1 more source

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source