Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients. [PDF]
Sharma P +5 more
europepmc +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Production and immunogenicity of a plant-produced beak and feather disease virus vaccine in Japanese quails. [PDF]
Mulondo G +7 more
europepmc +1 more source
Proteomics of Prostate Cancer Tissue Small Extracellular Vesicles Reveal Alteration of Metabolism
ABSTRACT Prostate cancer (PCa) is a leading male malignancy worldwide, with metabolic reprogramming being a critical hallmark of its progression. Extracellular vesicles (EVs) derived from tissues directly reflect the tumor microenvironment, offering unique insights into cancer pathophysiology that are unattainable through cell line or biofluid‐derived ...
Lijuan Yu +4 more
wiley +1 more source
Assessing Metabolite Interactions With Chloroplastic Proteins via the PISA Assay. [PDF]
Karlsson A +4 more
europepmc +1 more source
Proteomic and Lipidomic Profiling of Immune Cell‐Derived Subpopulations of Extracellular Vesicles
ABSTRACT Extracellular vesicles (EVs) are heterogeneous and play important roles in intercellular communication, contributing to physiological and pathological processes. Since few markers currently exist to differentiate subtypes of EVs, this study aimed to determine proteomic and lipidomic differences among four EV subpopulations. Large and small EVs
Anna Lischnig +6 more
wiley +1 more source
Analyzing Extracellular Vesicle-associated DNA Using Transmission Electron Microscopy at the Single EV-level. [PDF]
Tsering T, Nadeau A, Rak J, Burnier JV.
europepmc +1 more source
Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall +4 more
wiley +1 more source
How the JCI's most-cited paper sparked the field of lipoprotein research. [PDF]
Brown MS, Goldstein JL.
europepmc +1 more source
Studying large biomolecules as sedimented solutes with solid-state NMR. [PDF]
Shi F, Zhang T, Li J, Shi C, Xiang S.
europepmc +1 more source

