Results 111 to 120 of about 117,512 (352)

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Model selection and model averaging on mortality of upper gastrointestinal bleed patients [PDF]

, 2018
Model Selection (MS) is known to produce uncertainty into model-building process. Besides that, the process of MS is complex and time consuming. Therefore, Model Averaging (MA) had been proposed as an alternative to overcome the issues.
Mohd Padzil, Siti Aisyah, Khuneswari Gopal Pillay, Pillay, Khuneswari Gopal, Noraini Abdullah, Mohd Salleh, Rohayu, Abdullah, Noraini, Rohayu Mohd Salleh, Siti Aisyah Mohd Padzil   +7 more
core  

Polyethersulfone/Graphene Oxide Ultrafiltration Membranes from Solutions in Ionic Liquid

, 2017
Novel high flux polyethersulfone (PES) ultrafiltration membranes were fabricated by incorporating different amounts of graphene oxide (GO) sheets to PES as nanofillers.
Mahalingam, Dinesh, Nunes, Suzana. P., Kim, Dooli   +2 more
core   +1 more source

Application of Submerged Ultrafiltration in Pretreatment of Flue Gas Desulfurization Wastewater [PDF]

, 2022
Jiageng Zhang, Zheng‐Feng Wang, Jiguang Huang, Chao Cheng, Heng Zhang, Dan Gao   +5 more
openalex   +1 more source

Machine Learning‐Enhanced Ultrasensitive Immuno‐CRISPR Array Facilitates Early Diagnosis of Alzheimer's Disease by Detecting Multiple Plasma Biomarkers

Advanced Science, EarlyView.
This work presents a CRISPR‐based, ultrasensitive multiplex protein detection array capable of simultaneously analyzing six plasma biomarkers associated with Alzheimer's disease (AD). By integrating antibody‐mediated signal transduction, recombinase polymerase amplification, and spatially encoded CRISPR‐Cas12a, the system achieves detection sensitivity
Liding Zhang, Changwen Yang, Qian Yao, Xuewei Du, Shuai Ding, Yaoqiang Shi, Can Sheng, Ming Wang, Ying Han, Haiming Luo   +9 more
wiley   +1 more source

In vitro evaluation of critical ultrafiltration fluxes and transmembrane pressure in a high flux dialyzer

Scientific Reports
In patients treated with haemodiafiltration, high convection volumes are considered beneficial. However it leads to pressure instability and membrane fouling.
Siavash Sohan Gir, Nathalie Gayrard, Alain Ficheux, Jonas Laget, Chantal Cazevieille, Àngel Argilés, Flore Duranton   +6 more
doaj   +1 more source

Oxygen‐Tolerant Photo‐Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA‐ATRP) for High‐Throughput Synthesis of Polymer Bioconjugates

Angewandte Chemie, EarlyView.
Oxygen‐tolerant photo‐induced miniaturized accelerated atom transfer radical polymerization (OPTIMA‐ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub‐ambient (4°C) temperature and atmospheric conditions, without prior degassing, in less than 10 min, at an ultra‐small scale (< 50 µL) in ...
Arman Moini Jazani, Roksana Wygoda, Hironobu Murata, Mozhdeh Madadi, Grzegorz Przesławski, Krzysztof Matyjaszewski   +5 more
wiley   +2 more sources

Alkali Recycling from Rice Straw Hydrolyzate by Ultrafiltration: Fouling Mechanism and Pretreatment Efficiency

, 2015
Alkaline pretreatment of lignocellulosic biomass produced certain amounts of alkaline-soluble lignin and phenolic compounds in the hydrolyzate, which might bring a negative effect on the alkali reuse for continuous biomass pretreatment.
Yinhua Wan (1547833), Li, Yun, Benkun Qi (1547836), Wan, Yinhua, Qi, Benkun, Jianquan Luo (405062), Luo, Jianquan, Yun Li (692280)   +7 more
core   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source