Results 121 to 130 of about 117,512 (352)

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Degomagem de óleo de soja por ultrafiltração [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Alimentos.O refino tradicional do óleo de soja bruto consiste em submeter o produto às etapas de degomagem (retirada dos ...
Schuck, Marinês
core  

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Further analysis of permeate flux for membrane ultrafiltration along a solid-rod tubular module

, 2009
Predicting equations for the permeate flux of membrane ultrafiltration in a tubular module with a steel rod inserted concentrically were derived from momentum and mass balances with the application of the resistance-in-series model, coupled with the ...
葉和明; Yeh, Ho-ming; Dong, Jin-hong
core  

Separation of protein mixtures by an integrated electro-ultrafiltration-electrodialysis process

, 2015
An integrated process for improving selectivity and permeate flux in ultrafiltration based protein fractionation was developed by combining electrodialysis (ED) with electro-ultrafiltration (EUF).
Ghosh, Raja, Wan, Yinhua, Qi, Benkun, Li, Jing, Chen, Guoqiang, Song, Weijie   +5 more
core   +1 more source

Comparative Composition and Antioxidant Activity of Peptide Fractions Obtained by Ultrafiltration of Egg Yolk Protein Enzymatic Hydrolysates [PDF]

, 2011
Bertrand P. Chay Pak Ting, Yoshinori Mine, Lekh Raj Juneja, Tsutomu Ōkubo, Sylvie F. Gauthier, Yves Pouliot   +5 more
openalex   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

A study on cross-flow ultrafiltration with various membrane orientations

, 2013
In this study, the flux behavior of an-inclined flat-membrane cross-flow ultrafiltration was investigated. The experiment was conducted using a cellulose ester membrane (10,000 MWCO) and dextran T500 as the test solution.
Cheng, Tung-Wen, Cheng, Tung-Wen; Lin, Chih-Ta   +1 more
core   +1 more source

Identification of the Allergenic Ingredients in Reduning Injection by Ultrafiltration and High-Performance Liquid Chromatography [PDF]

, 2016
Fang Wang, Cunyu Li, Yunfeng Zheng, Hongyang Li, Wei Xiao, Guoping Peng   +5 more
openalex   +1 more source