Results 111 to 120 of about 103,585 (306)

NIR‐II Imaging‐Guided Photothermal Activation of a TRPV4‐Targeted Nanoplatform Delivering Cycloastragenol to Promote Microglia Reprogramming and α‐Synuclein Clearance in Parkinson's Disease

Advanced Science, EarlyView.
ABSTRACT Current therapies for Parkinson's disease (PD) fail to concurrently address α‐synuclein (α‐syn) aggregation and microglia‐mediated neuroinflammation. Herein, we engineer a near‐infrared‐II (NIR‐II) phototheranostic nanoplatform, CAG/FD1080@MM‐aTRPV4, for synergistic regulation of microglial function and real‐time monitoring of PD pathology. We
Hsuan Lo, Linjuan Feng, Shiying Li, Lik Hang Hugo Tse, Xuehan Wang, Xingyang Zhao, Shaoheng Ma, Xin Li, Yanjuan Gu, Wing‐Tak Wong   +9 more
wiley   +1 more source

Real‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer

Advanced Science, EarlyView.
Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...
Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang   +8 more
wiley   +1 more source

A Carrier Phase Ultrafiltration and Backflow Recovery Technique for Purification of Biological Macromolecules

Membranes
A simple carrier phase based ultrafiltration technique that is akin to liquid chromatography and is suitable for medium-to-large volume sample preparation in the laboratory is discussed in this paper.
Raja Ghosh
doaj   +1 more source

Influence of Polyethylene Glycol Additive on Performance of Polysulfone and Polyethersulfone Membrane

Journal of Mechanical Engineering and Sciences, 2014
This paper focuses on the performance of polysulfone (PSf) and polyethersulfone (PES) ultrafiltration membranes with polyethylene glycol (PEG). The aim of this study is to determine the effect of PEG as an additive in producing PSf and PES membrane. The
Siti Hawa Mohamad, Hasan Zuhudi Abdullah, Maizlinda Izwana Idris, Zawati Harun, Ahmad Fauzi Ismail, Muhamad Zaini Yunos, Sulaiman Hasan   +6 more
doaj   +1 more source

Ultrafiltration Membranes for Microdialysis

Hungarian Journal of Industry and Chemistry
Porous asymmetric polysulfone ultrafiltration membranes were prepared via the nonsolvent-induced phase separation process. The composition of the casting solution was optimized to achieve the required transport properties before membranes in the form of hollow fibers were prepared and characterized.
Zbynek Pientka, Zuzana Doubkova
openaire   +1 more source

Redox‐Responsive Polymeric Nanocapsules for Enhanced Tumor‐Targeted Delivery of Antimicrobial Peptides

Advanced Science, EarlyView.
This study presents a modular redox‐responsive nanocapsule platform that enables enhanced tumor‐targeted delivery of antimicrobial peptides. Using melittin as an example, the system achieves controlled activation within the tumor microenvironment, improving intratumoral accumulation while minimizing systemic toxicity.
Lin Tang, Yajian Li, Xiaoyin Lv, Jianmei Guo, Yijia Zhang, Yuqi Lin, Kaili Nie, Jian Zeng, Ming Zhang, Qiong Dai   +9 more
wiley   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Three-dimensional numerical study of flow characteristic and membrane fouling evolution in an enzymatic membrane reactor

, 2018
In order to enhance the understanding of membrane fouling mechanism, the hydrodynamics of granular flow in a stirred enzymatic membrane reactor was numerically investigated in the present study.
Hu, Xu-Qu, Luo, Jian-Quan, Wang, Xing-Yi, Wu, Pai-Qing, Zhang, Hai-Cheng   +4 more
core   +1 more source

Green ultrafiltration membranes

, 2009
Green ultrafiltration ...
Medina-Gonzalez, Yaocihuatl, Remigy, Jean-Christophe   +1 more
openaire   +2 more sources

Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs

Advanced NanoBiomed Research, EarlyView.
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna, Thomas Mayer, Di Zhang, Matthias Marczynski, Carolin A. Rickert, Fabio Henkel, Lennart J. K. Weiss, Friedrich C. Simmel, Yuxia Luan, Oliver Lieleg   +9 more
wiley   +1 more source