Results 131 to 140 of about 104,320 (310)

Cancer‐Associated Fibroblast‐Derived Sphingosine‐1‐Phosphate Activates a MALL–SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng   +16 more
wiley   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song   +10 more
wiley   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

open access: yesAdvanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz   +2 more
wiley   +1 more source

Small vesicles, big potential: A review of innovative exosome delivery and molecular mechanisms in preclinical myocardial infarction models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin   +2 more
wiley   +1 more source

MagNanoTrap‐Anreicherung ermöglicht ultrasensitive Quantifizierung gemischter Nanoplastikpartikel aus Umweltwasserproben

open access: yesAngewandte Chemie, EarlyView.
Fe3O4‐Nanopartikel, beschichtet mit dem bifunktionalen Peptid LCI‐DZ‐MBP1, wobei LCI an die Eisenoxidoberfläche bindet und MBP1 als universelles kunststoffbindendes Peptid fungiert, ermöglichen in Kombination mit Pyrolyse‐Gaschromatographie/Massenspektrometrie (Py‐GC/MS) eine effiziente Anreicherung sowie eine präzise Detektion und Quantifizierung ...
Maochao Mao   +5 more
wiley   +1 more source

FLUX PROFILES AND MATHEMATICAL MODELING OF FOULING MECHANISM FOR ULTRAFILTRATION OF KONJAC GLUCOMANNAN

open access: yesScientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2016
This study was focused on principles and fouling analysis of konjac glucomannan (KGM) separation using ultrafiltration system. Two Polyethersulfone membranes (PES) having molecular weight cut-off of 10 and 20 kDa were used.
NITA ARYANTI   +2 more
doaj  

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