Advanced Science, EarlyView.A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song +6 more
wiley +1 more source
Membrane‐aided simultaneous reaction–separation for liquid phase products
AIChE Journal, EarlyView.Abstract Conventionally, reaction and separation are conducted as separate steps in liquid‐phase manufacturing, with products formed during reaction and subsequently separated from unreacted reagents, solvents, and byproducts. Integrating these steps into a simultaneous reaction–separation process can improve efficiency and reduce costs.
Yihan Song +4 more
wiley +1 more source
Interfacial Polymerization on Polyethersulfone Ultrafiltration Membrane to Prepare Nanofiltration Layers for Dye Separation. [PDF]
Polymers (Basel), 2023 Liu L, Wu W, Jin X, Luo X, Wu L.
europepmc +1 more source
Safety and Feasibility of Magnetic Separation‐Based Blood Purification
Advanced NanoBiomed Research, EarlyView.We present the preclinical biological safety and translational feasibility of a magnetic nanoparticle‐based extracorporeal blood purification platform for removal of disease‐causing blood factors. ISO 10993‐compliant studies and exaggerated worst‐case exposure models demonstrate efficient nanoparticle extraction (≥99.9%), favorable biocompatibility ...
Carlos A. Mora +11 more
wiley +1 more source
Integrated biorefinery for cellulosic ethanol and spherical nanolignin production from coconut waste
Biofuels, Bioproducts and Biorefining, EarlyView.Abstract Green coconut waste was subjected to different fractionation methods to obtain integrated lignin nanoparticles and cellulosic ethanol. Pretreatment with gradual addition of dilute sulfuric acid provided a higher structural hemicellulose precursor yield (68.2%).
Ricardo Marchezan Farias de Mesquita +7 more
wiley +1 more source
Mechanistic models for intermittent haemodialysis and haemodiafiltration clearance
British Journal of Clinical Pharmacology, EarlyView.Haemodialysis has been used clinically for more than 70 years, but data regarding the clearance of medicines during dialysis are often based on studies with outdated, less efficient dialysers. Moreover, dialysis clearance is still frequently estimated using empirical approaches which lack mechanistic interpretability, are not readily generalizable ...
Laila Nassar +2 more
wiley +1 more source
Removal of Algae and Algal Toxins from a Drinking Water Source Using a Two-Stage Polymeric Ultrafiltration Membrane Process. [PDF]
Polymers (Basel), 2023 Zhang F, Xiong J, Zhang C, Wu X, Tian Y.
europepmc +1 more source
THE COMMERCIAL POTENTIAL OF NEW DAIRY PRODUCTS FROM MEMBRANE TECHNOLOGY [PDF]
Membrane filtration technologies are capable of creating entirely new, more functional food products. In this regard, potential new dairy products include high-protein, low-lactose fluid milk, high-protein, low-lactose ice cream, and non-far yogurt made ...
Siebert, John W. +2 more
core
Biotechnology and Bioengineering, EarlyView.ABSTRACT Persistence of HCPs remains a major purification challenge in biopharmaceutical manufacturing with direct consequences for product quality, patient safety, and regulatory compliance. Over the last two decades, deeper insights into the mechanisms driving HCP persistence have clarified why certain proteins evade removal during purification ...
Younghoon Oh +10 more
wiley +1 more source
Reduction of Ultrafiltration Membrane Fouling by the Pretreatment Removal of Emerging Pollutants: A Review. [PDF]
Membranes (Basel), 2023 Zhang J +6 more
europepmc +1 more source