Results 21 to 30 of about 41,850 (265)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Ultrasonic phased array flexible coupling detection of defects in high-voltage cable terminal lead seals

Frontiers in Mechanical Engineering
High-voltage cable terminal lead seals may develop defects such as holes, cracks, or delamination due to substandard installation quality or external forces during operation.
Peng Ziping, Zheng Jishi, Zhen Zhiming, Huang Yaosheng, Li Xiaobin, Cai Qiushen   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

B-Scan Imaging and 3D Visualization of Hardened Layer Depth Profile in Linear Guide Rails Based on Ultrasonic Shear Wave Backscattering Technique

Acoustics
In order to measure the depth profile of the heat-treated case-hardened layer of linear guides, this paper proposes a B-scan imaging and 3D visualization method for detecting the depth profile of the case-hardened layer of linear guides based on the ...
Peiqiang Chen, Lingtong Chen, Mingyang Xue, Chenlong Yang   +3 more
doaj   +1 more source

Numerical Simulation and Experimental Study of Fluid-Solid Coupling-Based Air-Coupled Ultrasonic Detection of Stomata Defect of Lithium-Ion Battery

Sensors, 2019
Aiming at the characteristics of the periodic stacking structure of a lithium-ion battery core and the corresponding relationship between the air-coupled ultrasonic transmission initial wave and the wave propagation mode in each layer medium of a lithium-
Honggang Li, Zhenggan Zhou
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Occluded Grape Cluster Detection and Vine Canopy Visualisation Using an Ultrasonic Phased Array

Sensors, 2021
Grape yield estimation has traditionally been performed using manual techniques. However, these tend to be labour intensive and can be inaccurate. Computer vision techniques have therefore been developed for automated grape yield estimation.
Baden Parr, Mathew Legg, Stuart Bradley, Fakhrul Alam   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Ultrasonic Quantitative Inspection of Brazed Joints in Aluminum Alloy Honeycomb Panels for Urban Rail Transit Vehicles

Chengshi guidao jiaotong yanjiu
ObjectiveFor quality inspection of brazed joints in aluminum alloy honeycomb panels, applying destructive testing methods may result in low inspection efficiency and serious material waste.
Yuting LIN, Shi CHEN, Yuxin DU, Xiaoyu CHANG, Guanghao ZHOU   +4 more
doaj   +1 more source