Results 21 to 30 of about 6,589 (215)

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Ultrasonic Resonance Fatigue Testing of 6082 Aluminum Alloy

Metals
This study explores the fatigue properties of EN AW-6082-T6 aluminum alloy in the gigacycle range (106–109 cycles), using ultrasonic resonance fatigue testing at 20 kHz in a push–pull mode with a symmetric load cycle (R = −1).
Diyan M. Dimitrov, Stoyan D. Slavov, Desislava Y. Mincheva, Adélio M. S. Cavadas   +3 more
doaj   +1 more source

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

NIMS fatigue data sheet on gigacycle fatigue properties of A2017 (Al-4.0Cu-0.6Mg) aluminium alloy

Science and Technology of Advanced Materials: Methods
The new fatigue data sheets, Nos. 135 and 136, disclose the gigacycle fatigue properties of A2017-T4 aluminium alloys. No. 135 shows gigacycle fatigue test results at a stress ratio of R =  −1 up to 1010 cycles, obtained by rotating bending fatigue ...
Yoshiyuki Furuya, Hideaki Nishikawa, Hisashi Hirukawa   +2 more
doaj   +1 more source

Ultrasonic and Conventional Fatigue Endurance of Aeronautical Aluminum Alloy 7075-T6, with Artificial and Induced Pre-Corrosion

Metals, 2020
Ultrasonic and conventional fatigue tests were carried out on the AISI-SAE AA7075-T6 aluminum alloy, in order to evaluate the effect of artificial and induced pre-corrosion.
Ishvari F. Zuñiga Tello, Marijana Milković, Gonzalo M. Domínguez Almaraz, Nenad Gubeljak   +3 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Research on Fatigue Damage of Compressor Blade Steel KMN-I Using Nonlinear Ultrasonic Testing

Shock and Vibration, 2017
The fatigue damage of compressor blade steel KMN-I was investigated using nonlinear ultrasonic testing and the relation curve between the material nonlinearity parameter β and the fatigue life was obtained.
Pengfei Wang, Weiqiang Wang, Jianfeng Li
doaj   +1 more source

Slip Localization Intensification Mediated by Grain Boundary Sliding in a Polycrystalline Nickel‐Based Superalloy

Advanced Engineering Materials, EarlyView.
The temperature dependence of fatigue behavior in nickel‐based superalloys is investigated through high‐resolution measurements of plastic localization. While increasing temperature reduces localization and enhances fatigue performance in René 88DT, Inconel 718 exhibits a sharp degradation at intermediate temperature due to intensified slip ...
M. Calvat, D. Anjaria, I. Woo, C. Bean, D. Texier, J. C. Stinville   +5 more
wiley   +1 more source