Results 221 to 230 of about 2,766,732 (290)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Identification and quantification of <i>Enterococcus faecalis</i> by real-time quantitative pcr during endodontic treatment. [PDF]

Front Dent Med
Attavar SH, Kapoor R, Harish SK, Shetty V, Shetty S.   +4 more
europepmc   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Effect of ultrasonic versus laser-activated irrigation on smear layer removal - An <i>in vitro</i> analysis. [PDF]

Bioinformation
Pawar O, Patel RN, Karade PM, Chowdhury C, Srivastava R, Mustafa M.   +5 more
europepmc   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

The Impact of Periodontal Instrumentation on Enamel and Cementum: A Narrative Review. [PDF]

Dent J (Basel)
Lodigkeit M, Lipski M, Schuster L, Dammaschke T, Dura W, Mochol M, Mazurek-Mochol M.   +6 more
europepmc   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Recent advances in transducers for through-tissue ultrasonic power transfer. [PDF]

Prog Biomed Eng (Bristol)
Chu Y, Naderi A, Wu H, Xue X, Oelze ML, Jiang X.   +5 more
europepmc   +1 more source

Application of Ultrasonic Osteotome in Segmental Resection and Removal of Cage During Revision Surgery for Intervertebral Disc Space Infection After Lumbar Fusion. [PDF]

Orthop Surg
Liu J, Ouyang Y, Zhang X, Zhang Q, Fu C, Zhao F.   +5 more
europepmc   +1 more source

Different irrigation solutions in calcium hydroxide removal: Do high-frequency ultrasonic and laser activation make the difference? [PDF]

Lasers Med Sci
Eminsoy Avcı AT, Eraslan Akyüz İ, Topçuoğlu HS.   +2 more
europepmc   +1 more source