Results 1 to 10 of about 204,251 (274)

A targeting microbubble for ultrasound molecular imaging [PDF]

PLOS ONE, 2015
Microbubbles conjugated with targeting ligands are used as contrast agents for ultrasound molecular imaging. However, they often contain immunogenic (strept)avidin, which impedes application in humans. Although targeting bubbles not employing the biotin-(
Eckersley, R, Haskard, DO, McConnell, E, Nihoyannopoulos, P, Nourshargh, S, Seddon, JM, Sennoga, CA, Tang, M-X, Yeh, JS-M   +8 more
core   +11 more sources

The role of ultrasound-driven microbubble dynamics in drug delivery : from microbubble fundamentals to clinical translation [PDF]

, 2019
In the last couple of decades, ultrasound-driven microbubbles have proven excellent candidates for local drug delivery applications. Besides being useful drug carriers, microbubbles have demonstrated the ability to enhance cell and tissue permeability ...
De Smedt, Stefaan, Deprez, Joke, Lajoinie, Guillaume, Lentacker, Ine, Roovers, Silke, Segers, Tim, Versluis, Michel   +6 more
core   +15 more sources

Low-intensity focused ultrasound targeted microbubble destruction reduces tumor blood supply and sensitizes anti-PD-L1 immunotherapy

Frontiers in Bioengineering and Biotechnology, 2023
Immune checkpoint blockade (ICB) typified by anti-PD-1/PD-L1 antibodies as a revolutionary treatment for solid malignancies has been limited to a subset of patients due to poor immunogenicity and inadequate T cell infiltration.
Nianhong Wu, Yuting Cao, Ying Liu, Ying Liu, Ying Zhou, Hongye He, Rui Tang, Li Wan, Can Wang, Xialin Xiong, Linhong Zhong, Pan Li   +11 more
doaj   +1 more source

A novel targeted multifunctional nanoplatform for visual chemo-hyperthermia synergy therapy on metastatic lymph nodes via lymphatic delivery

Journal of Nanobiotechnology, 2021
Background Distant metastasis to vital organs is the major contributor to breast cancer mortality, and regional lymph node metastasis is an important facilitator of distant metastasis and recurrence in this cancer.
Weiwei Liu, Xiaoping Ye, Lingyun He, Juan Cheng, Wenpei Luo, Min Zheng, Yaqin Hu, Wei Zhang, Yang Cao, Haitao Ran, Lu Yang   +10 more
doaj   +1 more source

Cancer cell membrane-coated nanoparticles for bimodal imaging-guided photothermal therapy and docetaxel-enhanced immunotherapy against cancer

Journal of Nanobiotechnology, 2021
Background Mono-therapeutic modality has limitations in combating metastatic lesions with complications. Although emerging immunotherapy exhibits preliminary success, solid tumors are usually immunosuppressive, leading to ineffective antitumor immune ...
Qiaoqi Chen, Liang Zhang, Lin Li, Mixiao Tan, Weiwei Liu, Shuling Liu, Zhuoyan Xie, Wei Zhang, Zhigang Wang, Yang Cao, Tingting Shang, Haitao Ran   +11 more
doaj   +1 more source

Biomimetic nanoprobe-augmented triple therapy with photothermal, sonodynamic and checkpoint blockade inhibits tumor growth and metastasis

Journal of Nanobiotechnology, 2022
Background Comprehensive antitumor therapy through integrated multimodal means has drawn increasing attention owing to its high efficiency and metastasis suppression.
Xiaohong Lin, Tao He, Rui Tang, Qianru Li, Nianhong Wu, Yin Zhou, Hongye He, Li Wan, Ju Huang, Qinqin Jiang, Yixin Zhong, Zhuoyan Xie, Zhongqian Hu, Yang Zhou, Pan Li   +14 more
doaj   +1 more source

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Journal of Nanobiotechnology, 2021
Background Recent studies have demonstrated that multidrug resistance (MDR) is a critical factor in the low efficacy of cancer chemotherapy. The main mechanism of MDR arises from the overexpression of P-glycoprotein (P-gp), which actively enhances drug ...
Weixi Jiang, Lei Su, Meng Ao, Xun Guo, Chen Cheng, Yuanli Luo, Zhuoyan Xie, Xingyue Wang, Junrui Wang, Shuling Liu, Yang Cao, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou, Jianli Ren   +15 more
doaj   +1 more source

Photochemically-driven highly efficient intracellular delivery and light/hypoxia programmable triggered cancer photo-chemotherapy

Journal of Nanobiotechnology, 2023
Background Using nanotechnology to improve the efficiency of tumor treatment represents a major research interest in recent years. However, there are paradoxes and obstacles in using a single nanoparticle to fulfill all the requirements of complex tumor ...
Wei Zhang, Cuncheng Zhang, Chao Yang, Xingyue Wang, Weiwei Liu, Mi Yang, Yang Cao, Haitao Ran   +7 more
doaj   +1 more source

Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy

Journal of Nanobiotechnology, 2021
Background Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment.
Jingxue Wang, Ju Huang, Weichen Zhou, Jiawen Zhao, Qi Peng, Liang Zhang, Zhigang Wang, Pan Li, Rui Li   +8 more
doaj   +1 more source

Laser-activated nanoparticles for ultrasound/photoacoustic imaging-guided prostate cancer treatment

Frontiers in Bioengineering and Biotechnology, 2023
Prostate cancer (PCa) is the most common malignant tumor in men. Prostate-specific membrane antigen (PSMA), which is overexpressed on the surface of Prostate cancer cells, may serve as a potential therapeutic target.
Linkang Xiao, Linkang Xiao, Yunfang Wu, Yunfang Wu, Junyong Dai, Junyong Dai, Weili Zhang, Yang Cao   +7 more
doaj   +1 more source