Results 201 to 210 of about 225,866 (281)

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

Septin5 deficiency impairs both recent and remote contextual fear memory. [PDF]

Mol Brain
Ageta-Ishihara N, Fukumasu N, Sakakibara K, Fujii K, Koshidaka Y, Katsuragawa S, Tanigaki K, Hiramoto T, Kang G, Hiroi N, Fukazawa Y, Miyakawa T, Takao K, Kinoshita M.   +13 more
europepmc   +1 more source

Dapansutrile preserves pancreatic beta‐cell function by regulating insulin vesicle membrane fusion and mitochondrial homeostasis

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims/Hypothesis Pancreatic beta‐cell dysfunction is pivotal in diabetes pathogenesis, with the NOD‐like receptor protein 3 (NLRP3) inflammasome playing a crucial role. Dapansutrile (DAPA), a novel NLRP3 inhibitor, demonstrates promise in diabetes management.
Ying Wu, Hongxing Fu, Min Zhu, Yuanfa Yao, Luhong Jin, Xihua Lin, Jiaqiang Zhou   +6 more
wiley   +1 more source

Author Correction: Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet. [PDF]

Sci Rep
Sheng Q, Xiao X, Prasadan K, Chen C, Ming Y, Fusco J, Gangopadhyay NN, Ricks D, Gittes GK.   +8 more
europepmc   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

<p>Cigarette smoke combined with <i>Klebsiella pneumoniae</i> induce damage to the air‑blood barrier in chronic obstructive pulmonary disease rats via the MAPK/NF‑κB/IκBα pathway</p>. [PDF]

Mol Med Rep
Tian Y, Xu K, Lu R, Li K, Shao X, Liao Y, Zhao Y, Qiu Z, Dong H, Liu X.   +9 more
europepmc   +1 more source

Recent advances of emergent extraction technologies to enhance bioactive compounds extraction of microalgae—An overview towards application in cosmetics

International Journal of Cosmetic Science, EarlyView.
Microalgae extracts show immense potential in cosmetics for their bioactivities; emerging extraction techniques enhance bioactive compound yield from microalgae. Abstract Microalgae have attracted significant interest in numerous sectors, particularly in the cosmetic industries, owing to their rich composition of bioactive compounds. This paper aims to
Alireza Mousakhani Ganjeh, Lucília da P. da Silva, Carlos A. Pinto, Rosário Martins, Alexandra P. Marques, Jorge A. Saraiva   +5 more
wiley   +1 more source

A New Quantitative Metric for Precise Classification of Diabetic Podocyte Injury Using Scanning Electron Microscopy. [PDF]

Microsc Microanal
Rooney F, Allamargot C, Williquett J, Sun H.   +3 more
europepmc   +1 more source

Requirement of group I lytic polysaccharide monooxygenase for turnover of chitinous cuticle during moulting in two forest pest beetles, Monochamus alternatus and Psacothea hilaris

Insect Molecular Biology, EarlyView.
Group I LPMO15‐1 cDNAs from two economically important forest insect pests, M. alternatus and P. hilaris, were cloned. MaLPMO15‐1 and PhLPMO15‐1 show a similar pattern of expression during late stages of development. RNAi for LPMO15‐1 causes failure of adult eclosion in both M. alternatus and P. hilaris.
Daehyeong Kim, Subbaratnam Muthukrishnan, Karl J. Kramer, Yasuyuki Arakane, Mi Young Noh   +4 more
wiley   +1 more source