Results 41 to 50 of about 441,292 (304)
A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceOn the Ultraviolet Rays.
JOURNAL OF THE ILLUMINATING ENGINEERING INSTITUTE OF JAPAN, 1928 此の講演は自分の研究の結果を發表したのではなく, 今日まで多くの人々によつて研究された事柄を目次に示すやうに分類し, 紫外線の呈する多くの作用を述べ, それが實際上如何なる方面に應用されて居るかを解説したものである。日光は保健上有効であると云ふことは二千年の昔から知られて居たが, それは學術的に根据はなかつた。日光の中に紫外線のあることは十九世紀の始めに發見された。それから漸次日光の中の紫外線が人體に有効であると云ふことが知られ, 紫外線の分量の多い高山に療養所が出來るやうになつた。而して今日では尚張い紫外線を出す人工的の光源を病症治癒のために用ひるやうになつた。既は紫外線の有する殺菌作用及生理的亢進作用に依るのである。又紫外線の有する螢光作用及燐光作用は寳石, 手形 ...openaire +2 more sourcesOperation of a free-electron laser from the extreme ultraviolet to the water window [PDF]
, 2007 We report results on the performance of a free-electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent extreme-ultraviolet radiation source have been measured.T. Jezynski, REDLIN H, T. Hott, Di Pirro, G, Pucyk, P., Simon, C, CIANCHI A, NUNEZ T, E. Sombrowski, Castro, P, M. Körfer, P. Spanknebel, Zagorodnov, I, N. Baboi, SANDNER W, Brovko, O.I, Dardis, J, Poletto, L, D. Proch, Stephan, Frank, Cubaynes, D., Saldin, E. L., Feldhaus, J, Kavanagh, K., KOSTIN D, W. Ackermann, Ch, Gerth, Castellano, M., Khodyachykh, S, Pchalek, N., C. Pagani, SCHMIDT B, A. A. Sorokin, Frisch, J, PLONJES E, Yurkov, M. V., Ivanisenko, Y., KRASSILNIKOV M, Azima, A: Baboi, N, V. Miltchev, L. Petrosyan, I. Will, Oppelt, Anne, T. Edwards, H., K. Pozniak, Shabunov, A.V., Kavanagh, K, Cubaynes, D, Han, J.H., V. Yurkov, M., Shabunov, A., Feldhaus, J., Kostin, D, N, Schnepp, S., Kostin, D., Monaco, Laura, A. Sorokin, A., Roensch, J, Grecki, M., SOROKIN AA, R. Treusch, WEILAND T, M. Kollewe, Koprek, W., Yurkov, M., HAN JH, N. Pchalek, Yeates, Patrick, Schneidmiller, E. A., Tsakov, I, Flottmann, K, L. Saldin, E., HACKER K, Ross, M., Choroba, S., Sandner, W, C. Simon, R. Kammering, Kuhlmann, M., KATALEV V, Schmitz, M, BEUTNER B, Decking, W, Schneidmiller, E.A., SOMBROWSKI E, Saldin, E., I. Brovko, O., Plonjes, E, GRIMM O, CHIADRONI E, TIEDTKE K, Luna, H, G. Petrosyan, Delsim-Hashemi, H., J. Frisch, GERTH C, Grabosch, H, IVANISENKO Y, Limberg, T., Katalev, V, Nuez, T, FAATZ B, DOHLUS M, VOGEL E, K. Flöttmann, Roensch, Juliane, Krassilnikov, Mikhail, Schreiber, S., JALMUZNA W, Rossbach, J, Tischer, M, H. T. Edwards, L. Lilje, WINTER A, LUNA H, A. Bolzmann, LILJE L, Ackermann, W, MOLLER WD, Prat, E., STEPHAN F, SCHMITZ M, A. Delserieys, Stulle, F, K. Wittenburg, Lewis, C. L. S., Seidel, M, WITTENBURG K, M. Sachwitz, Gerth, C, Brovko, O.I., M. Seidel, S. Schnepp, KOCHARYAN V, Jaeschke, E., Staykov, L., Ivanisenko, H.-J. Y., B. Steffen, Katalev, V., DARDIS J, J. Pedregosa Gutierrez, Saldin, E.L., Brandt, A, H. Redlin, Korfer, M, Kennedy, E, J. T. Costello, Kennedy, E.T., SCHMUSER P, KUBE G, SIMON C, Staykov, L, Edwards, H.T., Spanknebel, P., Muller, W, Korepanov, S, Miltchev, V., Pozniak, K, C. L. S. Lewis, F. Stulle, Schreiber, Siegfried, Schmuser, P, Honkavaara, K, Sorokin, A. A., Roehrs, M, Will, Ingo, Vogel, E., Hüning, M., Roehrs, M., Miltchev, Velizar, A: Baboi, D. Kostin, Spesyvtsev, R., Rehlich, K., NICOLOSI, PIERGIORGIO, NAPIERALSKI O, TSAKOV I, PAPARELLA R, A. Azima, Düsterer, S., Petrosyan, B., Schmidt, B., I. Zagorodnov, Winter, A, C.h. Gerth, Pozniak, K., KAVANAGH K, CASTELLANO M, E. Plönjes, J. Roensch, Wellhofer, M, Hahn, U, M. Ross, Poletto, L., Asova, Galina, Luong, M., D. Sertore, Castellano, M, YEATES P, N. Golubeva, Asova, G., FROHLICH L, W. F. O. Müller, Redlin, H, Thom, H., BOLZMANN A, Asova, G, Dohlus, M, Sertore, D, Han, H., Krassilnikov, M., Müller, W.F.O., Saldin, E, Dardis, J., Martins, M, Lewis, Ciaran, Möller, W. D., H. Luna, M. Castellano, Redlin, H., Schneider, J. R., D. Cubaynes, Jaeschke, Eberhard, Yurkov, M.V., Weiland, T., JEZYNSKI T, Romaniuk, R., K. Honkavaara, Richter, M., Delsim-Hashemi, H, Luna, H., A. Eckhardt, FLOTTMANN K, Tiedtke, K, Michelato, P, Khodyachykh, S., Weiland, Thomas, RYBNIKOV V, Lipka, S., BRINKMANN R, Martins, M.,, Golubeva, N., Zagorodnov, I., KOLLEWE M, A. Winter, Görler, M., Ivanisenko, Y, Löhl, F., MARTINS M, Hahn, U., Schmüser, P., Sachwitz, M., Weise, H, Napieralski, O., LUONG M, M. Görler, M. Schmitz, Korepanov, S., KOREPANOV S, Schnepp, Sascha, Pchalek, N, SACHWITZ M, M. Kuhlmann, E. Prat, Sombrowski, E, Richter, M, W. Wurth, CATANI L, V. Rybnikov, THOM H, Oppelt, A., SCHNEPP S, Simon, C., Costello, J. T, Faatz, B., Sorokin, A.A., SPANKNEBEL P, Delsim Hashemi, H, A. Schneidmiller, E., RICHTER M, Bolzmann, A, L. Catani, Sombrowski, E., Paparella, R., LIPKA D, B. Beutner, PAGANI C, Gensch, U., Körfer, M., Nicolosi, P., Yurkov, M, Radcliffe, P, Frisch, Josef, Radcliffe, P., Schlarb, H., Vogel, E, Petersen, B., Kollewe, M., SERTORE D, Rybnikov, V, Balandin, V., Lohl, F, Meyer, M, Napoly, O, KHODYACHYKH S, Proch, D., Shabunov, A, Kennedy, Eugene T., S. Choroba, Ayvazyan, V, Grabosch, H.-J., Nolle, D, Napieralski, O, J. R. Schneider, PRAT E, J. Bähr, W. Sandner, Bahr, J, B. Petersen, A. V. Shabunov, Treusch, R., R. Schneider, J., Edwards, H. T., V. Ayvazyan, Baboi, N., NOLLE D, FRISCH J, H. Han, J., Grimm, O., Ross, Marc, CHOROBA S, M. Krassilnikov, FELDHAUS J, Eckhardt, A., MILTCHEV V, PFLUGER J, Bahr, J., L. Staykov, KORFER M, H. Delsim Hashemi, H. J. Grabosch, CUBAYNES D, KUHLMANN M, O. Napieralski, Han, Jang Hui, M. Meyer, KOPREK W, F. O. Müller, W., U. Hahn, Bähr, Jürgen W., Costello, John T., Shabunov, A. V., ACKERMANN W, LOHL F, POZNIAK K, Frisch, J., Garvey, T., Brovko, O. I., ZAGORODNOV I, Seidel, M., K. Tiedtke, Bolzmann, A., Oppelt, A, SALDIN EL, Balandin, V, Petroysan, L., Decking, W., Edwards, H.T, JAESCHKE E, Treusch, R, T. Kennedy, E., G. Asova, Lewis, C, Lipka, Dirk, Hacker, K, WELLHOFFER M, T. Garvey, CASTRO P, Chiadroni, E., Honkavaara, K., S. Düsterer, HUNING M, ROSS M, Winter, A., CIANCHI, ALESSANDRO, Brandt, A., Pagani, C., Will, I., Roensch, J., DECKING W, ROSSBACH J, Wellhöfer, M., E. Chiadroni, Brinkmann, R, V. Balandin, DELSERIEYS A, Frohlich, L, Kube, G, Schneider, J, Petrosyan, L., ROMANIUK R, Wendt, M, PEDREGOSA GUTIERREZ J, E. L. Saldin, F. Stephan, KENNEDY ET, M. Martins, SHABUNOV AV, J. Pedregosa-Gutierrez, Wittenburg, K, T. Limberg, Grabosch, Hans-Jürgen, Grabosch, H., ECKHARDT A, Wurth, W, Jalmuzna, W, Schmitz, M., Delserieys, A, Steffen, Bernhard, D. Möller, W., Müller, W., Moller, W, Gretchko, V., Schnepp, S, M. Tischer, Zagorodnov, Igor A., Sachwitz, M, Castro, P., PUCYK P, S. Schreiber, Yeates, P, ROENSCH J, Spanknebel, P, Vogel, E. M., NAPOLY O, Cianchi, A, RADCLIFFE P, YURKOV MV, Jezynski, T., Martins, M., Pedregosa-Gutierrez, J, K. Hacker, Chiadroni, E, Edwards, H. T, Michelato, P., U. Gensch, Möller, W., GRECKI M, Rehlich, K, R. Spesyvtsev, Edwards, A., Lewis, S., R. Brinkmann, W. D. Möller, Brinkmann, R., E. T. Kennedy, Dohlus, M., Delserieys, A., W. Decking, Ackermann, Wolfgang, O. Napoly, Wurth, W., P. Nicolosi, Hott, T., AYVAZYAN V, HAHN U, Toleikis, S, Han, J, Kavanagh, Kevin D., Sandner, Wolfgang, M. V. Yurkov, I. Tsakov, D. Nölle, Lilje, L, Catani, L., Weise, H., MULLER WFO, SIMROCK S, ROEHRS M, Monaco, L, Dohlus, Martin, STAYKOV L, M. Hüning, J. H. Han, S. Toleikis, Plönjes, E., Schneidmiller, E, Meyer, M., A. Brandt, V. Shabunov, A., DUSTERER S, Körfer, Markus, Beutner, B., Sandner, W., Garvey, T, Hott, T, OPPELT A, MEYER M, P. Castro, Petrosyan, G., Flöttmann, A., Stephan, F., Wendt, M., Jezynski, W., Grimm, O, Gensch, U, Grecki, M, Kennedy, E. T., Stephan, F, SCHNEIDMILLER EA, Yeates, P., Zapfe, K., Steffen, B, M. Grecki, B. Faatz, COSTELLO JT, A. Oppelt, STULLE F, T. Weiland, Rossbach, J., GORLER M, SEIDEL M, Schmidt, B, SCHREIBER S, LIMBERG T, Brovko, I., Kocharyan, V., Kube, G., PETERSEN B, Azima, SCHLARB H, Schlarb, H, Faatz, B, PROCH D, Ross, M, Lipka, D., Schmüser, Peter, Trines, D., Schreiber, S, HONKAVAARA K, Simrock, S, Romaniuk, R, Khodyachykh, Sergiy, Pflüger, J., Miltchev, V, M. Richter, Rybnikov, V., Costello, J.T, Möller, W.D., Simrock, S., Jaeschke, E, Delserieys, Alice, Petrosyan, Bagrat, Stulle, F., BAHR J, WURTH W, Beutner, B, REHLICH K, GARVEY T, MICHELATO P, W. Jalmuzna, Pagani, Carlo, POLETTO L, Costello, T., K. Rehlich, Spesyvtsev, R, G. Kube, H. Thom, Gerth, Ch., Gensch, Ulrich, Tsakov, I., Schneider, J.R., S. Khodyachykh, E. A. Schneidmiller, Sorokin, A, Paparella, R, Michelato, Paolo, Toleikis, S., H. Weise, Martins, M., Corriea, Klose, K., Prat, E, P. Pucyk, Kammering, R, BALANDIN V, P. Schmüser, Catani, L, Fröhlich, L., TREUSCH R, Luong, M, Ch. Gerth, M. Dohlus, Costello, J.T., HOTT T, TRINES D, Krassilnikov, M, A. Cianchi, E. Jaeschke, Tsakov, Ivan, PETROSYAN L, Klose, K, V. Kocharyan, J. Pflüger, ASOVA G, L. Fröhlich, Edwards, H., K. Zapfe, MONACO L, PETROSYAN B, Napoly, O., Grimm, Oliver, Tischer, M., PETROSYAN G, Ayvazyan, V., SPESYVTSEV R, Koprek, W, K. Klose, Sertore, Daniele, Limberg, T, M. Wellhöfer, M. Roehrs, Staykov, Lazar, BRANDT A, GRABOSCH HJ, Pucyk, P, S. Korepanov, Golubeva, N, Petersen, B, Nölle, D., Lilje, L., WEISE H, Cianchi, A., Monaco, L., Pfluger, J, SCHNEIDER JR, WENDT M, Flöttmann, K., Kuhlmann, M, D. Trines, Ackermann, W., T. Costello, J., Brovko, O. I, O. I. Brovko, KLOSE K, O. Grimm, Eckhardt, A, J. Feldhaus, KAMMERING R, Sertore, D., Will, I, Schneidmiller, A., Proch, D, P. Michelato, GENSCH U, DELSIM HASHEMI H, PCHALEK N, Gorler, M, Jalmuzna, W., H. Schlarb, Tiedtke, K., Rossbach, Jörg, TOLEIKIS S, Y. Ivanisenko, L. S. Lewis, C., Müller, W. F. O., STEFFEN B, Dusterer, S, TISCHER M, R. Romaniuk, ZAPFE K., Flöttmann, Klaus, Wittenburg, K., Weiland, T, Nuñez, T., Nicolosi, P, Azima, A., Petrosyan, B, T. Nuñez, Kammering, R., H.-J. Grabosch, Steffen, B., Lipka, D, Dardis, John, EDWARDS HT, J. Rossbach, B. Schmidt, Kocharyan, V, Costello, J. T., AZIMA A, Kennedy, T., GOLUBEVA N, Huning, M, M. Luong, H. Delsim-Hashemi, DI PIRRO G, Jezynski, T, Sorokin, A., L. Monaco, M. Wendt, Trines, D, Di Pirro, G., Pedregosa-Gutierrez, J., R. Paparella, LEWIS CLS, B. Petrosyan, Schneider, R., L. Poletto, E. Vogel, BABOI N, WILL I, BROVKO OI, K. Kavanagh, F. Löhl, G. Di Pirro, Pedregosa Gutierrez, J, J. Dardis, Kollewe, M, P. Radcliffe, Pagani, C, Choroba, S, Thom, H, P. Yeates, Han, J. H., Petrosyan, G, V. Katalev, Müller, Wolfgang Franz Otto, Petrosyan, L, D. Lipka, Hacker, K., W. Koprek, S. Simrock, Schneider J R, Zapfe, K. (author), PedregosaGutierrez J, Edwards H T, Beutner, B. (author), Lewis C L S, Moller W D, Ayvazyan, V. (author), Asova, G. (author), Schneidmiller E A, Muller W F O, Yurkov M V, Balandin, V. (author), Brandt, A. (author), Gerth Ch, Han J H, Ackermann, W. (author), Costello J T, Azima, A. (author), Zapfe K, Sorokin A A, Saldin E L, DelsimHashemi H, Bähr, J. (author), Bolzmann, A. (author), Baboi, N. (author), Kennedy E T, Nicolosi P, Seidel, M. (author), Shabunov A V +761 morecore +2 more sourcesSPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin +17 morewiley +1 more source
