Results 51 to 60 of about 4,844,377 (373)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Phothotherapy of skin diseases: timeless classics
Клинический разбор в общей медицине, 2023 The review paper provides brief analysis of phototherapy methods used in various dermatoses. Phototherapy can be prescribed in combination with drugs or used solo.
Mariya V. Kail-Goryachkina
doaj +1 more source
Challenges in constructing genetic instruments for pharmacologic therapies [PDF]
arXiv, 2020 The genes that encode the targets of most therapies do not have rare variants with large-effect or common variants with moderate effects on the biomarker reflecting the pharmacologic action of the corresponding therapy. Therefore, providing genetic target validation for most therapies is challenging.
arxiv
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Melanogenesis and the Targeted Therapy of Melanoma
Biomolecules, 2022 Pigment production is a unique character of melanocytes. Numerous factors are linked with melanin production, including genetics, ultraviolet radiation (UVR) and inflammation.
Can Li, L. Kuai, Rutao Cui, X. Miao
semanticscholar +1 more source
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
core +2 more sources
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Pengembangan Fitur Keselamatan Mekanikal Blue Light Therapy Berbasis Motor Linear Terintegrasi
Medika TeknikaPada perkembangan teknologi di era globalisasi saat ini dapat mempengaruhi terhadap suatu perkembangan peralatan, diantaranya yaitu peralatan rumah tangga, perkantoran, industri hingga peralatan kesehatan.
Febrian Febrian +1 more
doaj +1 more source
Tumor Biology, 2017 Photodynamic therapy is widely used in the clinical treatment of tumors, especially skin cancers. It has been reported that the photosensitizer curcumin, in combination with ultraviolet radiation B, induces HaCaT cell apoptosis, and this effect may be ...
Yong Xin +5 more
doaj +1 more source
Squamous cell carcinoma in a patient with vitiligo of photo-covered skin
Indian Journal of Dermatology, 2014 Ultraviolet radiation is an important risk factor for the development of skin cancers. Melanin is known to protect the skin against harmful effects of ultraviolet radiation. Hence, vitiligo patients are at higher risk of developing such malignancies. But
Asok Gangopadhyay +2 more
doaj +1 more source