Results 161 to 170 of about 270,105 (271)

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola   +9 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Centralised by Design: Anglocentric Constitutionalism, Accountability and the Failure of English Devolution

open access: yesThe Political Quarterly, Volume 96, Issue 1, Page 189-198, January/March 2025.
Abstract The Labour manifesto in this year's election implied a radical restructuring of the UK state, the way in which England is governed and in relations across the United Kingdom. The aim of making English devolution the ‘default option’ is set against fifty years of unsuccessful and partial devolution initiatives which have failed to reverse the ...
John Denham, Janice Morphet
wiley   +1 more source

Prolapse of the Umbilical Cord [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1956
openaire   +2 more sources

Views from the Inside: Reflections on the Modern Hospital

open access: yesThe Political Quarterly, EarlyView.
Abstract There's a constant refrain in the press, on social media and from populist politicians that the NHS is dying on its feet. How accurate is this picture? This article takes a behind‐the‐scenes look at daily life in a modern, big city hospital. The Queen Elizabeth is now the biggest workplace in Birmingham.
Jon Bloomfield
wiley   +1 more source

Internal Consistency of the Hadlock Estimated Fetal Weight Reference: Methodological Analysis

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess the internal consistency of the Hadlock normal range for estimated fetal weight (EFW) and its clinical implications. Design Methodological analysis and retrospective observational audit. Setting Tertiary maternity hospital in Oxford, UK. Population Women with a non‐anomalous singleton pregnancy.
Theophilus K. Adu‐Bredu   +4 more
wiley   +1 more source

Impact of a Structured Caesarean Reduction Strategy on Perinatal Outcomes: A Retrospective Ecological Time‐Trend Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the long‐term impact of a structured, multidisciplinary CS reduction strategy in a high‐complexity Italian hospital. Design Retrospective ecological time‐trend study. Setting Tertiary obstetric care Italian centre. Sample 28 577 deliveries, ≥ 22 weeks' gestation, from 2014 to 2024 were analysed.
Stefania Fieni   +4 more
wiley   +1 more source

Prenatal Environmental Hypoxia Enhances Adult Hypoxia Tolerance in Brandt's Voles (Lasiopodomys brandtii): Behavioral and Transcriptomic Insights

open access: yesIntegrative Zoology, EarlyView.
Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li   +5 more
wiley   +1 more source

Uncovering the Process of Sexual Segregation: Male Early‐Life Individual Tactics Shape Its Onset and Affect Phenotypic Quality in a Large Mammal

open access: yesIntegrative Zoology, EarlyView.
Early‐life traits significantly influence sexual segregation patterns and phenotypic quality in male fallow deer. Males in better condition and those more risk‐prone left natal groups earlier with fewer returns to natal groups. However, males with frequent excursions back to natal groups compensated for initial body condition disadvantages.
Cong Yu   +8 more
wiley   +1 more source

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