Results 61 to 70 of about 83,052 (293)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Improvement of Gasless Laparoscopic Single-Site Lifting and Use in Surgery for Endometrial Carcinoma

Clinical and Experimental Obstetrics & Gynecology
Background: The operative field in gasless surgery is limited, and it is difficult to adequately expose the operative field when compared to the use of gas surgery.
Bingbing Zhao, Xinqiu Lu, Xuli Gan, Zhijun Yang, Li Li, Jieqing Zhang   +5 more
doaj   +1 more source

Umbilical artery aneurysm without aneuploidy and delivery of a live neonate

, 2022
OBJECTIVES: Umbilical artery aneurysm, a rare structural anomaly of the umbilical cord, is frequently associated with fetal aneuploidy, fetal growth restriction and fetal demise.
Tang, Xiangna, Lewis, Gregory K, Dawkins, Josette C   +2 more
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Diastasis of the rectus abdominis muscle prevalence in postpartum

Fisioterapia em Movimento
Introduction: Diastasis of the rectus abdominis muscle (DRAM) is characterized by the separation of the rectus abdominis muscles beams, caused by enlargement of the linea alba, a common condition during pregnancy.
Elaine Demartini, Keila Cristiane Deon, Eliane Gonçalves de Jesus Fonseca, Bruno Sérgio Portela   +3 more
doaj   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

A novel technique with cool-tip radiofrequency ablation for selective fetal reduction in complicated monochorionic twin

Taiwanese Journal of Obstetrics & Gynecology
Objective: To invent a novel method for selective fetal reduction in monochorionic (MC) twin using cool-tip radiofrequency ablation (RFA) and analysis the perinatal outcome.
Ting Yi Chu, Chih-Ping Chen, Pei-Chen Chen, Yu-Chen Chien, Hsing-Tse Yu, Liang-Ming Lo, T'sang-T'ang Hsieh, Steven W. Shaw   +7 more
doaj   +1 more source

Single-incision laparoscopic-assisted ileal resection for adult intussusception

Journal of Minimal Access Surgery, 2016
Adult intussuception is rare and laparotomy is required in most of the cases due to the potential pathologic underlying reasons. Although it is technically challenging, single-incision laparoscopic surgery can work as an alternative to laparotomy.
Hong Yu, Shuodong Wu, Renzhong Zhu, Xiaopeng Yu   +3 more
doaj   +1 more source

New Umbilical Manufacturing Method Eliminates Weight Limitation

, 2017
This paper will present a new manufacturing method for Umbilicals. The new bundling principle presented here has eliminated the weight and volume limitations of the conventional systems.
Arild Figenschou, Leif Høie, David Hickman   +2 more
core   +1 more source