Results 81 to 90 of about 81,975 (261)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

eLife, 2015
Vascular remodeling under conditions of growth or exercise, or during recovery from arterial restriction or blockage is essential for health, but mechanisms are poorly understood.
Nicolas Baeyens, Stefania Nicoli, Brian G Coon, Tyler D Ross, Koen Van den Dries, Jinah Han, Holly M Lauridsen, Cecile O Mejean, Anne Eichmann, Jean-Leon Thomas, Jay D Humphrey, Martin A Schwartz   +11 more
doaj   +1 more source

Characterizations of Umbilic Points of Isometric Immersions in Riemannian and Lorentzian Manifolds

Taiwanese Journal of Mathematics, 2016
Several characterizations of umbilic points of submanifolds in arbitrary Riemannian and Lorentzian manifolds are given. As a consequence, we obtain new characterizations of spheres in the Euclidean space and of hyperbolic spaces in the Lorentz-Minkowski space. We also prove the Lorentzian version of a classical result by Cartan.
Caballero, Magdalena, Rubio, Rafael María   +1 more
openaire   +3 more sources

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

THE LOCATION OF SPONTANEOUS RUPTURE OF THE UMBILICAL CORD, A MEDICO-LEGAL POINT [PDF]

The American Journal of the Medical Sciences, 1889
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openaire   +1 more source

Electrical‐Stimulation Hydrogel Electronic Skin for Sustainable Hybrid Biomechanical–Electromagnetic Energy Harvesting and Accelerating Wound Healing

Advanced Science, EarlyView.
A hybrid biomechanical–electromagnetic energy‐harvesting e‐skin is developed using a gelatin‐based outer matrix with a zwitterionic conductive inner layer. The e‐skin autonomously generates stable electrical stimulation from daily body motion and ambient electronics, enabling significantly enhanced wound healing bothin vitro and in vivo.
Syun‐Hong Chou, Ming‐Han Lu, Wei‐Chen Peng, Wei‐Chun Yang, Pei‐Yi Liu, Yu‐Hsuan Yang, Yi‐Lin Huang, Cheng‐Hung Tsai, Ting‐Yu Yang, Xuan Zhang, Zhi‐Xian Yan, Ying‐Chih Lai, San‐Yuan Chen   +12 more
wiley   +1 more source

Mecanismo de centralização: da insuficiência placentária à adaptação circulatória fetal Brain sparing effect: from placental insufficiency to fetal circulatory adaptation

Revista Brasileira de Ginecologia e Obstetrícia, 2008
A aplicação e o desenvolvimento da doplervelocimetria obstétrica apresentam base para conhecimento da insuficiência placentária e comprovam o comportamento dinâmico da circulação fetal em regime de hipóxia. Na prática clínica, tornou-se quase rotineira a
Juliana Marques Simões Villas-Bôas, Izildinha Maestá, Marcos Consonni   +2 more
doaj   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

An isolated umbilical point of a Willmore surface

Osaka Journal of Mathematics, 2004
This paper proves that the index of an isolated umbilic point on a Willmore surface does not exceed 1/2. The author first gives a simple explanation of why we know that there do indeed exist umbilic points on Willmore surfaces with index equal to 1/2 and hence the estimate is sharp.
openaire   +4 more sources

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source