Results 191 to 200 of about 193,599 (260)

Carbon Nanotube Hydrogels Reveal Threshold‐Dependent Regulation of Neuroblastoma Cell Growth and Maturation by Mechanical and Chemical Factors

open access: yesSmall Science, Volume 5, Issue 11, November 2025.
Poly(vinyl alcohol)/carbon nanotube (PVA/CNT) hydrogels with unprecedented CNT loading (75% w/w) were engineered as 3D scaffolds for nerve regeneration. By tuning Young's modulus (YM), CNT concentration, and pore size, distinct thresholds controlling cell coverage were identified. Optimized scaffolds achieved > 70% coverage and upregulated β‐3‐tubulin (
Bahaa Daou   +3 more
wiley   +1 more source

PENERAPAN MODEL WATERFALL DAN UML DALAM RANCANG BANGUN PROGRAM PEMBELIAN BARANGBERORIENTASI OBJEK PADA PT. FUJITA INDONESIA

open access: hybrid, 2021
Hardiyanto Hardiyanto   +4 more
openalex   +1 more source

Generating Logical Architectures from SysML Behavior Models

open access: yesSystems Engineering, Volume 28, Issue 6, Page 762-778, November 2025.
ABSTRACT Modeling solution‐neutral operating principles of system features as SysML behavior models enable systems engineers to specify reusable product features for a variety of similar products and to specify and document a product's functionality in an easy‐to‐understand manner.
Christian Granrath   +4 more
wiley   +1 more source

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades   +4 more
wiley   +1 more source

Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 22, Page 5517-5535, November 2025.
Abstract Background and Purpose Hepatocellular carcinoma (HCC), the third leading cause of cancer‐related deaths worldwide, has limited treatment options and high mortality rate. We previously used a bioinformatics approach to identify niclosamide (NIC) as a promising repurposed drug candidate for HCC.
Mingdian Tan   +6 more
wiley   +1 more source

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