Results 171 to 180 of about 187,911 (271)

Expansion of the Eastern Tropical North Pacific Oxygen Minimum Zone During the Last Deglaciation Recorded by Planktic Foraminifera

open access: yesPaleoceanography and Paleoclimatology, Volume 41, Issue 5, May 2026.
Abstract Climate change is currently driving the expansion of oxygen minimum zones (OMZs), areas of the open ocean with consistently low oxygen levels. Changes in temperature, productivity and consequent respiration, and water mass ventilation drive OMZ expansion and contraction with implications for ecosystem function and biogeochemical cycling ...
Rachel Alcorn   +7 more
wiley   +1 more source

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2307-2323, May 2026.
Background and purpose Opioids targeting the μ opioid receptor remain largely ineffective in neuropathic pain conditions, emphasizing the need for novel therapeutic strategies. MP135 was reported to reduce thermal nociception in naive animals by activating μ‐δ opioid receptor heteromers.
Perrine Inquimbert   +13 more
wiley   +1 more source

Specifying Services with UML and UML-RT

open access: yesElectronic Notes in Theoretical Computer Science, 2002
openaire   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2219-2235, May 2026.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind   +6 more
wiley   +1 more source

Determining structures of RNA conformers using AFM and deep neural networks. [PDF]

open access: yesNature
Degenhardt MFS   +13 more
europepmc   +1 more source

Districting in last‐mile delivery with stochastic customers

open access: yesInternational Transactions in Operational Research, Volume 33, Issue 3, Page 1636-1655, May 2026.
Abstract Due to the peculiarities of city streets, last‐mile logistics is typically organized using territory‐based routing approaches, which divide the city into a set of districts and assign drivers to deliver in one or more of them. This allows drivers to develop a deep understanding of the characteristics of each district, and clients benefit from ...
Maria Elena Bruni   +3 more
wiley   +1 more source

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