Results 151 to 160 of about 60,645 (326)

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

open access: yesThe FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero   +8 more
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

open access: yesThe FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior   +5 more
wiley   +1 more source

Az UML gyakorlati alkalmazásának bemutatása egy komplex rendszer elemzésén keresztül

open access: yes, 2007
Azért választottam szakdolgozat témának az UML-t, mert érdekelnek az alkalmazásfejlesztéssel kapcsolatos témák. Egy üzleti alkalazásnak olyan összetett szerkezete van, amelyet programkódokól már nehéz átlátni és talán lehetetlen a programban igény ...
Gellei, Csaba
core  

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

Az UML gyakorlati alkalmazásának bemutatása egy webáruház tervezése közben

open access: yes, 2011
UML bemutatása és annak egy példán keresztüli szemléltetése.BscProgramtervező ...
Podlovics, Ferenc
core  

Extensão para UML destinada à modelagem de variabilidade transversal em componentes através da orientação a aspectos [PDF]

open access: yes, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Ciência da Computação.O presente trabalho propõe uma extensão para a UML 1.4 (Unified Modeling Language) destinada à modelagem de ...
Winck, Diogo Vinícius
core  

Developing collaboration tool for virtual team using UML models

open access: diamond, 2021
Yasmin Makki Mohialden   +2 more
openalex   +2 more sources

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