Results 31 to 40 of about 5,243 (226)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Research on technical status date management for in-service aircraft based on S5000F
Hangkong gongcheng jinzhan, 2023 At present, due to lack of the domestic technical status data management standards for in-service aircraft, the data management is managed by multiple related parties and is not planed as a whole, the data is difficult to correlate and trace, so it ...
NIE Haoyu, ZHAO Wenwu
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
ModellingUnmanned surface vehicles (USVs) have great application prospects in defense, environmental surveillance and offshore energy due to their cost-effectiveness and long-duration mission ability.
Yifei Peng +3 more
doaj +1 more source
Using UML profiles to interchange DSML and UML models
2009 Third International Conference on Research Challenges in Information Science, 2009 A key requirement for MDD solutions is to have a modeling language that allows the correct representation of conceptual models. Nowadays, there are two options that are the most widely used for the definition of these modeling languages: 1) the specification of a domain-specific modeling language (DSML) or 2) the customization of UML.
Giachetti, Giovanni +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Domain Modeling in the Context of Ontology
Foundations of Computing and Decision Sciences, 2015 The domain knowledge represented by ontology should be widely used in the design process of information system. The aim of the paper is to outline a systematic approach of developing a CIM model (domain model, precisely) on the basis of a selected domain
Dubielewicz Iwona +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source