Results 41 to 50 of about 60,645 (326)
ModellingUnmanned surface vehicles (USVs) have great application prospects in defense, environmental surveillance and offshore energy due to their cost-effectiveness and long-duration mission ability.
Yifei Peng +3 more
doaj +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
, 2004 The paper presents Ontology UML Profile (OUP) that is based on OWL and a metamodel – Ontology Definition Metamodel. OUP is defined in the context of the MDA four-layer architecture and current the OMG’s effort for ontology development. The proposed UML profile enables usage of the well-known UML notation in ontology development more extensively.
Dragan Djuric +3 more
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Domain Modeling in the Context of Ontology
Foundations of Computing and Decision Sciences, 2015 The domain knowledge represented by ontology should be widely used in the design process of information system. The aim of the paper is to outline a systematic approach of developing a CIM model (domain model, precisely) on the basis of a selected domain
Dubielewicz Iwona +3 more
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Complex Systems Informatics and Modeling Quarterly, 2021 Business Information Systems research deals with the conceptualization, development, introduction, maintenance and utilization of systems for computer-assisted information processing within companies and enterprise-wide networks.
Ben Roelens
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UML specification of distributed system environments [PDF]
, 1999 The specification of distributed systems is a complex task, which is made easier by the use of object-oriented design methodologies. With the advent of UML as a standard notation for object-oriented software design, the application of this notation to ...
Waters, A. Gill, Akehurst, David H.
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2020 Scientific reproducibility is essential for the advancement of science. It allows the results of previous studies to be reproduced, validates their conclusions and develops new contributions based on previous research.
Benito M. Zaragozí +2 more
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