Results 101 to 110 of about 19,052 (304)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Life Transitions of the Unaccompanied Migrant children in Slovenia: Subjective Views

Dve Domovini, 2017
The article addresses the issue of unaccompanied migrant children seeking international protection in Slovenia and their perceptions of four different life transitions they experience through their journey: a transition across geographical spaces ...
Mateja Sedmak, Zorana Medarić
doaj   +1 more source

Integrating New Communities - Challenging Racism [PDF]

, 2004
In this report, the needs of new people hoping to settle in Ireland, and how these are responded to, provides the context in which racism in Ireland can be considered and one in which to identify opportunities where funding could make an important ...
Kieran McKeown, Madeleine Clarke
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Conditions de la parole pour des jeunes « harraga » en insertion à la Protection judiciaire de la jeunesse et impacts sur l’enseignement/apprentissage en français langue étrangère

Sociétés et Jeunesses en Difficulté, 2022
This article proceeds from a sociolinguistical and didactical research: “Multilingualism, mobility and language learning, from the complexity of language resources in context to their reflexive development in training”. This research was carried out in a
Françoise Hickel
doaj  

The "imaginary world" of nationalistic ethics: Feasibility constraints on Nordic deportation corridors targeting unaccompanied Afghan minors

Etikk i Praksis: Nordic Journal of Applied Ethics, 2018
This article examines Swedish, Danish and Norwegian governments’ participation in the European Return Platform for Unaccompanied Minors (ERPUM) project and its failed attempts to deport unaccompanied minors (UAMs) to Afghanistan.
Martin Lemberg-Pedersen
doaj   +1 more source

An Effective Model for Estimating Age in Unaccompanied Minors under the Italian Legal System. [PDF]

Healthcare (Basel), 2023
Cameriere R, Scendoni R, Ferrante L, Mirtella D, Oncini L, Cingolani M.   +5 more
europepmc   +1 more source

Challenges for the protection of unaccompanied foreign minors in the streets of Ceuta [PDF]

, 2019
Ceuta, as a Spanish enclave in Africa face specific challenges in terms of immigration. Due the proximity of Ceuta and Morocco, the residents of Moroccan provinces adjoining are exempted from visa requirements and can be authorized to enter and exit the
Carvalho da Silva, Jacqueline, García-España, Elisa   +1 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Comparing Expectations of Social Workers in Norwegian Trauma-Informed Care Institutions: Perspectives from Social Work Leadership and Young Unaccompanied Refugees

Journal of Comparative Social Work
Research: Balancing the expectations of social work leadership and minor, unaccompanied refugees is a key part of the social worker’s professional practice, in the context of Norwegian residential care institutions that have trauma-informed care at the ...
Linda Natalie Borho, Sarah Catherine Patricia Duff Hean, Wenche Hovland   +2 more
doaj   +1 more source