Results 91 to 100 of about 19,052 (304)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Unaccompanied Refugee Minors in Europe

open access: yesEuropean Journal of Psychotraumatology, 2019
In recent years, a growing number of unaccompanied refugee minors reach Western European countries in search of safety and well-being. Many of them are from Eritrea, Syria and Afghanistan, and have been confronted with war, violence and hardships in their home countries and during the journey.
Mooren, Trudy   +4 more
openaire   +1 more source

Arguments over solutions to the “surge” of Central American immigrant minors are based on myths about why they have come to the U.S. [PDF]

open access: yes, 2014
Recent weeks have seen increasing concern over the “surge” in undocumented minors arriving at the US-Mexico border, with Republicans and Democrats in Congress putting forward potential solutions to the apparent crisis.
Brenneman, Robert
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Coronavirus Disease 2019 Burden Among Unaccompanied Minors in US Custody. [PDF]

open access: yesClin Infect Dis, 2023
Foppiano Palacios C   +2 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Editorial: Unaccompanied Minors in Europe - Part II

open access: yesSocial Work and Society, 2017
To this date, there is a lack of data on the absolute number of people who became refugees in 2017. There are reasons to assume, though, that the global situation regarding flight and migration has not changed significantly since we published Part I of this special issue on"Unaccompanied Minors in Europe" in the fall of 2017.
Zeller, Maren, Sandermann, Philipp
openaire   +3 more sources

Uncertainty as a companion – different professionals experiences of health and illhealth among unaccompanied refugee minors [PDF]

open access: yes, 2016
Introduction: Millions of people are now fleeing their countries. An specially exposed group amongst these refugees are the unaccompanied refugee minors. These minors are a particularly vulnerable group in need of safety to achieve health which imply new
Vennman, Emma, Ånskog, Lisa
core  

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