Results 71 to 80 of about 4,594 (256)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Liminal resistance towards and within migratory hotspots – On the transformative potential of critical participatory action research with African unaccompanied minors in Italy [PDF]

open access: yes
openIn an age of migration, movement in-between and across both physical and symbolic borders becomes increasingly prevalent. Such liminal experiences are particularly unsettling for more vulnerable people on the move such as unaccompanied minors ...
REISCH, HANNA THERESA
core  

TIME ON THE MOVE AND THE PSYCHOSOCIAL OUTCOMES OF UNACCOMPANIED MINORS

open access: yesResearch in Education and Rehabilitation
This research aimed to examine the relationship between the psychosocial outcomes of unaccompanied minors and the time spent on the move.
Danijel Vasilj   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Promoting Supported Independent Living as an alternative care practice for unaccompanied minors : D2.1 Report on the analysis of integration context for unaccompanied minors in Spain [PDF]

open access: yes, 2020
The purpose of these reports is to analyse and assess the integration context and integration services provided to unaccompanied minors via semi-structured interviews with stakeholders in countries of project partners.
Universitat Autònoma de Barcelona. Departament d'Antropologia Social i Cultural   +3 more
core  

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Art as an intervention strategy with unaccompanied minors

open access: yes, 2019
This book is a collective work that collects some of the research papers (in translated and expanded form) that have already been presented in the Italian version (Traverso, 2018).
Francesca Audino
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Approaches to unaccompanied minors following status determination in Ireland

open access: yes, 2018
In 2017, over 650,000 people lodged an application for international protection in the EU, 31,395 of whom were unaccompanied minors, constituting more than a 30 per cent increase since 2014.
Groarke, Sarah, Arnold, Samantha
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

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