Results 41 to 50 of about 4,594 (256)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Career Guidance for Unaccompanied Young Migrants. A Report on an Italian Experience
Journal for Perspectives of Economic Political and Social Integration, 2020 Unaccompanied foreign minors are migrant children without their parents, relatives, or other adults. In Italy, especially in Sicily, an increasing number of young, non-European Union foreigners arrive daily in search of a new life and work opportunities.
Paola Magnano, Andrea Zammitti
doaj +1 more source
The adaptation of foreign minors between risk and protective factors
Encyclopaideia, 2021 The frame of risk and protection factors in relation to the social and educational adaptation of unaccompanied foreign minors is very complex. This qualitative Systematic Review aims to analyze the most recent scientific research on psychological ...
Marinella Muscarà +3 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
The “Brown Paper Syndrome”: Unaccompanied Minors and Questions of Status
Refuge, 2002 In principle, the Charter of Rights and Freedoms grants equal rights to all persons residing in Canadian territory. In practice, it is clear that some populations are more “equal” than others.
Catherine Montgomery
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Unaccompanied Minors, Migration
, 2020 Unaccompanied minors are children who migrate internationally without their parent or primary adult guardian. However, the term ‘ unaccompanied minor’ is the subject of debate within childhood studies, and many researchers prefer the term ‘separated ...
Rosen, R
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source