Results 41 to 50 of about 15,884 (263)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Prevalence and determinants of hypertension unawareness in Egyptian adults: a cross-sectional study of data from the 2015 Egyptian Health Issues Study

The Lancet Global Health, 2020
Background: Hypertension is a major risk factor for cardiovascular disease that affects 1·3 billion people and accounts for 17·9 million deaths worldwide annually.
Saeed S Soliman, MD, FRCGP, Emily H Guseman, MD, Zelalem T Haile, MD, Gillian H Ice, MD   +3 more
doaj   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Questionnaire to Assess the Knowledge, Attitude, and Awareness Regarding Coma among the Informal Caregivers of Comatose Patients: An Observational Study

Journal of the Scientific Society
Background: Comatose is a perilous state that is contemplated as a medical emergency. Coma impacts the primary caregiver’s daily living that has debilitating effects.
Sanjiv Kumar, Aishwarya Swaminathan
doaj   +1 more source

Preference-Based Unawareness [PDF]

SSRN Electronic Journal, 2011
Morris (1996, 1997) introduced preference-based definitions of knowledge and belief in standard state-space structures. This paper extends this preference-based approach to unawareness structures (Heifetz, Meier, and Schipper, 2006, 2008). By defining unawareness and knowledge in terms of preferences over acts in unawareness structures and showing ...
openaire   +3 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Awareness of sensorimotor adaptation to visual rotations of different size. [PDF]

PLoS ONE, 2015
Previous studies on sensorimotor adaptation revealed no awareness of the nature of the perturbation after adaptation to an abrupt 30° rotation of visual feedback or after adaptation to gradually introduced perturbations.
Susen Werner, Bernice C van Aken, Thomas Hulst, Maarten A Frens, Jos N van der Geest, Heiko K Strüder, Opher Donchin   +6 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Hypertension unawareness among Chinese patients with first-ever stroke

BMC Public Health, 2016
Background The low rates of hypertension treatment and control, partly due to its unawareness, are the main causes of the high stroke incidence in China.
Qinqin Cao, Pei Pei, Jun Zhang, Jillian Naylor, Xinying Fan, Biyang Cai, Qiliang Dai, Wen Sun, Ruidong Ye, Ruifeng Shi, Keting Liu, Yongjun Jiang, Wenhua Liu, Fang Yang, Wusheng Zhu, Yunyun Xiong, Xinfeng Liu, Gelin Xu   +17 more
doaj   +1 more source