Results 61 to 70 of about 15,884 (263)

Targeting DNGR‐1 with Fangchinoline Elevates Dendritic Cell Antigen Cross‐Presentation‐Mediated Antitumor Immunity in Melanoma

Advanced Science, EarlyView.
Fangchinoline is identified as a small‐molecule DNGR‐1 modulator that enhances dendritic‐cell cross‐presentation of tumor antigens. By engaging DNGR‐1 and activating Syk–Nox2 signaling, it promotes phagosomal ROS, antigen escape, MHC‐I presentation, and CD8+ T‐cell priming, thereby strengthening antitumor immunity and sensitizing tumors to PD‐1 ...
Yuan Liao, Zhenyang Ren, Jing Zhou, He Luo, Yuling Li, Dan Chen, Yuxiao Jiang, Canzhe Li, Mengyi Zheng, Anqi Li, Yao Wang, Yang Zhang, Dingye Wang, Yanjun Jiang, Jiangyong Gu, Biaoyan Du, Yafei Shi, Fang Liu, Jianyong Xiao, Kun Wang   +19 more
wiley   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Prevalence, determinants and association of unawareness of diabetes, hypertension and hypercholesterolemia with poor disease control in a multi-ethnic Asian population without cardiovascular disease

Population Health Metrics, 2019
Background To explore the prevalence and determinants of unawareness of diabetes, hypertension and hypercholesterolemia and its association with poor disease control in a multi-ethnic Asian population without cardiovascular disease (CVD).
Ryan E. K. Man, Alvin Hong Wei Gan, Eva K. Fenwick, Alfred Tau Liang Gan, Preeti Gupta, Charumathi Sabanayagam, Nicholas Tan, Kah Hie Wong, Tien Yin Wong, Ching-Yu Cheng, Ecosse L. Lamoureux   +10 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Reasoning about knowledge of unawareness [PDF]

Games and Economic Behavior, 2009
Awareness has been shown to be a useful addition to standard epistemic logic for many applications. However, standard propositional logics for knowledge and awareness cannot express the fact that an agent knows that there are facts of which he is unaware without there being an explicit fact that the agent knows he is unaware of.
Joseph Y. Halpern, Leandro Chaves Rêgo
openaire   +3 more sources

Hierarchical Physical‐Cyber Encryption via Metasurface‐Encoded Holographic Keys

Advanced Science, EarlyView.
ABSTRACT Physical‐layer encryption based on metasurfaces has emerged as a promising alternative to conventional algorithmic cryptography by embedding security into physical processes. However, most existing metasurface‐based encryption schemes operate within single‐stage or static frameworks, where correct physical illumination directly reveals the ...
Zhen Liu, Changhong Dai, Wei Zhu, Ruisheng Yang, Bohan Zhang, Lei Zhang, Bobo Du, Shengxiang Wang, Guangwei Hu   +8 more
wiley   +1 more source

Relationship between workers’ lifestyles and high blood pressure unawareness [PDF]

Cadernos de Saúde Coletiva
Background: Lack of awareness of hypertension is a major deterrent to the prevention of complications arising from this condition. Objective: This study aimed to identify the lifestyle characteristics associated with a higher prevalence of high blood ...
Tamyres Araújo Andrade Donato, Renata da Silva Gomes, Márcio Galvão Oliveira, Danielle Souto de Medeiros, Daniela Arruda Soares, José Andrade Louzado, Kelle Oliveira Silva, Matheus Lopes Cortes, Sóstenes Mistro, Welma Wildes Amorim, Clavdia Nicolaevna Kochergin, Vanessa Moraes Bezerra   +11 more
doaj   +1 more source

Unawareness of hyposmia in patients with idiopathic Parkinson’s disease

Annals of Movement Disorders, 2020
BACKGROUND: Loss of olfaction is a hallmark of neurodegenerative disorders such as idiopathic Parkinson’s disease (PD) and it may precede the clinical syndrome of PD by many years. Olfactory bulb is probably the earliest site of pathology in PD.
Utkarsh Patel, Charulata Savant Sankhla
doaj   +1 more source

Standard State Space Models of Unawareness (Extended Abstract) [PDF]

Electronic Proceedings in Theoretical Computer Science, 2016
The impossibility theorem of Dekel, Lipman and Rustichini has been thought to demonstrate that standard state-space models cannot be used to represent unawareness. We first show that Dekel, Lipman and Rustichini do not establish this claim.
Peter Fritz, Harvey Lederman
doaj   +1 more source

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source