Results 91 to 100 of about 1,121,600 (292)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

A Modified Regularization Method for Inverse Problems of Nonhomogeneous Differential Operator Equation

Journal of Mathematics
This paper investigates an abstract nonhomogeneous backward Cauchy problem governed by an unbounded linear operator in a Hilbert space H. The coefficient operator in the equation is assumed to be unbounded, self-adjoint, positive, and to possess a ...
Nihed Teniou
doaj   +1 more source

Second regularized trace of a differential operator with second order unbounded operator coefficient given in a finite interval

, 2017
In this work, we establish a formula for the second regularized trace of a second orderdifferential operator with unbounded operator coefficient given in a finite interval.
Bakşi, Özlem, Özlem Bakşi, Yonca Sezer, Serpil Karayel, Sezer, Yonca, Karayel, Serpil   +5 more
core   +1 more source

Boundary-domain integral equations for variable coefficient Dirichlet BVP in 2D unbounded domain [PDF]

, 2019
In this paper, the Dirichlet boundary value problem for the second order stationary diffusion elliptic partial differential equation with variable coefficient is considered in unbounded (exterior) two dimensional domain.
S. E. Mikhailov, T. T. Dufera, Mikhailov, S, Dufera, TT   +3 more
core   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

A Note on the Drag Coefficient of Steady Flow of Non-Newtonian, Power-Law Fluids across Unbounded Two-Dimensional Bodies at Low Reynolds Numbers

Fluids, 2017
The flow of a non-Newtonian, power-law fluid, directed normally to long, two-dimensional horizontal bodies, is considered in the present note. It is found that for low Reynolds numbers ( Re ≤ 0.1 ) and a low power-law index (shear-thinning fluids ...
Asterios Pantokratoras
doaj   +1 more source

A support theorem for the filter under infinite dimensional noise and unbounded observation coefficient

, 1999
peer reviewedIn this paper we consider a nonlinear filtering problem with an unbounded observation coefficient, correlated noises, and a signal process driven by an infinite dimensional Brownian motion.
SCHILTZ, Jang
core   +1 more source

SDF‐1 Attenuates Oocyte Quality Decline During Reproductive Aging Through Autophagy‐Enhanced Stress Granule Scavenging

Advanced Science, EarlyView.
SDF‐1 levels decline significantly with maternal aging. Exogenous supplementation restores meiotic spindle morphology, chromosomal alignment, and mitochondrial function while reducing oxidative stress in aged oocytes. Mechanistically, SDF‐1 enhances autophagic activity to clear accumulated stress granules, thereby rescuing fertilization competence and ...
Rui Long, Meng Wang, Ruolin Mao, Hong Chen, Juepu Zhou, Xiangfei Wang, Zheng Yuan, Ri‐Cheng Chian, Nan Xiao, Qingsong Xi, Yimin Shu, Lei Jin, Lixia Zhu   +12 more
wiley   +1 more source

Asymptotic behaviour of nonlinear wave equations in a noncylindrical domain becoming unbounded

Electronic Journal of Differential Equations, 2017
We study the asymptotic behaviour for the solution of nonlinear wave equations in a noncylindrical domain, becoming unbounded in some directions, as the time t goes to infinity. If the limit of the source term is independent of these directions and t,
Aissa Aibeche, Sara Hadi, Abdelmouhcene Sengouga   +2 more
doaj