Results 71 to 80 of about 742,712 (288)
An anisotropic Dirichlet system including unbounded coefficients
Discrete and Continuous Dynamical Systems - SThis paper focuses on an anisotropic system driven by (p, q)- Laplacian operators with unbounded coefficients depending on the solution, and whose lower order-terms exhibit full dependence on the solution and its gradient. The main results establish the existence of solutions and the uniform boundedness of the solution set.
Dumitru Motreanu +2 more
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Advanced Science, EarlyView.Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen +13 more
wiley +1 more source
Large solutions to non-divergence structure semilinear elliptic equations with inhomogeneous term
Advances in Nonlinear Analysis, 2017 Motivated by the work [9], in this paper we investigate the infinite boundary value problem associated with the semilinear PDE Lu=f(u)+h(x){Lu=f(u)+h(x)} on bounded smooth domains Ω⊆ℝn{\Omega\subseteq\mathbb{R}^{n}}, where L is a non-divergence ...
Mohammed Ahmed, Porru Giovanni
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Advanced Science, EarlyView.ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin +13 more
wiley +1 more source
Elliptic Operators on Rd with Unbounded Coefficients
Journal of Differential Equations, 2001 { u t (t, x)= 1 2 tr[C(x) Du(t, x)]+(F(x), Du(t, x)) , (1.2) u(0, x)=,(x). If the coefficients C and F are continuous and bounded and C is nondegenerate then a satisfactory theory of both equations is available; see [18], [15]. The situation changes dramatically when the coefficients F and C are unbounded.
Da Prato, Giuseppe, Goldys, Beniamin
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Advanced Science, EarlyView.A highly sensitive SERS‐based platform measures PD‐L1 expression on EpCAM+ circulating EVs from cancer patients undergoing immunotherapy. Monitoring dynamic changes after treatment reveals that reduced EpCAM+ EV PD‐L1 levels associate with improved long‐term clinical outcomes, establishing a non‐invasive approach for tracking immune checkpoint ...
Byeonggeol Mun +15 more
wiley +1 more source
On the Operator Sturm-Liouville Problem with Unbounded Operator Coefficients in Boundary Condition [PDF]
Journal of Applied and Computational MechanicsIn this study, we carry out the spectral analysis of operators generated by the Sturm-Liouville equation and boundary conditions, where both contain unbounded operator coefficients and a spectral parameter. Such problems model many processes in classical
Nigar Aslanova +3 more
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Advanced Science, EarlyView.Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha +4 more
wiley +1 more source
Advanced Science, EarlyView.A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo +18 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source