Results 41 to 50 of about 11,243 (308)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2009 Boundary value problem is studied in the unbounded domain. Uniqueness of the problem is proven with the help of the extreme principle. Existence of the problem is established by methods of separation of variables and integral equations.
M. Kh. Ruziev
doaj +1 more source
ON ELLIPTIC PROBLEMS IN DOMAINS WITH UNBOUNDED BOUNDARY [PDF]
Proceedings of the Edinburgh Mathematical Society, 2006 AbstractThe paper deals with problems of the type $-\Delta u+a(x)u=|u|^{p-2}u$, $u\gt0$, with zero Dirichlet boundary condition on unbounded domains in $\mathbb{R}^N$, $N\geq2$, with $a(x)\geq c\gt0$, $p\gt2$ and $p\lt2N/(N-2)$ if $N\geq3$. The lack of compactness in the problem, related to the unboundedness of the domain, is analysed. Moreover, if the
Molina, J., MOLLE, RICCARDO
openaire +6 more sources
Generalized Active Information: Extensions to Unbounded Domains [PDF]
BIO-Complexity, 2020 In the last three decades, several measures of complexity have been proposed. Up to this point, most of such measures have only been developed for finite spaces. In these scenarios the baseline distribution is uniform. This makes sense because, among other things, the uniform distribution is the measure of maximum entropy over the relevant space ...
Daniel Andrés Díaz-Pachón +1 more
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Axioms, 2020 The purpose of this work is to prove the existence and uniqueness of a class of nonlinear unilateral elliptic problem (P) in an arbitrary domain, managed by a low-order term and non-polynomial growth described by an N-uplet of N-function satisfying the ...
Omar Benslimane +2 more
doaj +1 more source
Special wave finite and infinite elements for the solution of the Helmholtz equation [PDF]
, 2003 The theory and the formulation of the special wave finite elements are discussed, and the special integration schemes for the elements are developed.
Sugimoto, Rie
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source