Results 41 to 50 of about 882,980 (308)

Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?

Viruses, 2017
Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo.
Malachy I. Okeke, Arinze S. Okoli, Diana Diaz, Collins Offor, Taiwo G. Oludotun, Morten Tryland, Thomas Bøhn, Ugo Moens   +7 more
doaj   +1 more source

Short-Term Forecasting and Uncertainty Analysis of Photovoltaic Power Based on the FCM-WOA-BILSTM Model

Frontiers in Energy Research, 2022
Aiming to solve the problem that photovoltaic power generation is always accompanied by uncertainty and the short-term prediction accuracy of photovoltaic power (PV) is not high, this paper proposes a method for short-term photovoltaic power forecasting (
Wensi Cao, Junlong Zhou, Qiang Xu, Juan Zhen, Xiaobo Huang   +4 more
doaj   +1 more source

The impacts of uncertainty shocks on the Global Financial Cycle: a multiperspective SVAR analysis [PDF]

, 2023
reservedThis thesis aims to investigate the role of global uncertainty shocks in affecting the Global Financial Cycle (GFC). Three kinds of uncertainty are considered: financial uncertainty, the uncertainty surrounding economic policies and the ...
PITTINI, RUGGERO
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Model-Based Optimisation and Control Strategy for the Primary Drying Phase of a Lyophilisation Process

Pharmaceutics, 2020
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are ...
Brecht Vanbillemont, Niels Nicolaï, Laurens Leys, Thomas De Beer   +3 more
doaj   +1 more source

Uncertainty analysis of large risk assessment models with applications to the railway safety and standards board safety risk model

, 2009
Probabilistic risk analysis aims to assess the safety risk of a system so that actions can then be taken to improve safety. Uncertainty however always exists in modelling. For more informed decision making, uncertainty in the outputs of the model must be
Cheng, Doasheng, Cheng, Daosheng
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Uncertainty analysis of discharge coefficient predicted for rectangular side weir using machine learning methods

Journal of Hydrology and Hydromechanics
The present study used three machine learning models, including Least Square Support Vector Regression (LSSVR) and two non-parametric models, namely, Quantile Regression Forest (QRF) and Gaussian Process Regression (GPR), to quantify uncertainty and ...
Seyedian Seyed Morteza, Kisi Ozgur
doaj   +1 more source