Results 51 to 60 of about 882,980 (308)
, 2020 Our contemporary society consists of increasingly complex systems-of-systems in which technical and social subsystems influence each other. Multi-models reflect this complexity and are useful to analyse these complex socio-technical systems. They consist
Drent, Alexander (author)
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Robust adaptation decision-making under uncertainty: Real Options Analysis for water storage [PDF]
, 2020 Planning for climate change adaptation is challenging due to the inherent uncertainty associated with future climate changes. Although we have a range of climate projections, even these cannot provide a definitive picture of the future, with little ...
Dittrich, R +5 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
International Journal of Sustainable Energy, 2019 In this work, the impact of intermittent renewable energy sources on total production cost is evaluated, using annual data regarding the isolated power system of the island of Cyprus.
Pavlos Nikolaidis +2 more
doaj +1 more source
EcoEnsemble: A general framework for combining ecosystem models in R
Methods in Ecology and Evolution, 2023 Often there are several complex ecosystem models available to address a specific question. However, structural differences, systematic discrepancies and uncertainties mean that they typically produce different outputs.
Michael A. Spence +2 more
doaj +1 more source
UNCERTAINTY ANALYSIS OF PRODUCTION FORECAST IN SHALE SYSTEMS [PDF]
, 2019 This research evaluates the impact of decision making and uncertainty associated with production forecast in shale oil and gas wells; over 11000 wells completed in the Barnett & Haynesville plays and more than 2000 wells from the Permian Basin.
MABADEJE, ADEMIDE
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Designing a Thermoacoustic Cooler for Energy Applications: Experimental Insights
EnergiesThermoacoustic devices, such as refrigerators and heat pumps, present unique measurement challenges due to the simultaneous presence of rapidly fluctuating acoustic parameters and more stable thermal variables.
Leszek Remiorz +3 more
doaj +1 more source