Results 71 to 80 of about 24,503,001 (297)
A Procedure to Perform Multi-Objective Optimization for Sustainable Design of Buildings
Energies, 2016 When dealing with sustainable design concepts in new construction or in retrofitting existing buildings, it is useful to define both economic and environmental performance indicators, in order to select the optimal technical solutions.
Cristina Brunelli +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Extremely Efficient Design of Organic Thin Film Solar Cells via Learning-Based Optimization
Energies, 2017 Design of efficient thin film photovoltaic (PV) cells require optical power absorption to be computed inside a nano-scale structure of photovoltaics, dielectric and plasmonic materials.
Mine Kaya, Shima Hajimirza
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The Impact of Macroeconomic and Financial Uncertainty on GDP Growth: a Quantile Regression Analysis [PDF]
openThis dissertation investigates the relationship between financial and macroeconomic uncertainty and the business cycle. Utilizing quantile regression analysis and US data, the study examines the effects of changes in uncertainty on the entire ...
GJERGJI, GRETA
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Uncertainty and growth of the firm [PDF]
Using data from a survey of 1097 Dutch firms we investigate the relation between growth of the firm and uncertainty. We focus on the impact of uncertainty on various types of investment, employment demand, and expected maturity of the firm.
Lensink, Robert +2 more
core
Cogent Food & Agriculture, 2019 As tea (Camellia sinensis L.) yield strongly determined by local environmental conditions, thus assessing the potential impact of the seasonal and inter-annual climate variability on regional crop yield has become crucial.
Esack Edwin Raj +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source