Results 71 to 80 of about 3,309,856 (292)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A Procedure to Perform Multi-Objective Optimization for Sustainable Design of Buildings
Energies, 2016 When dealing with sustainable design concepts in new construction or in retrofitting existing buildings, it is useful to define both economic and environmental performance indicators, in order to select the optimal technical solutions.
Cristina Brunelli +4 more
doaj +1 more source
Metrology and Measurement Systems, 2020 In the framework of non-destructive evaluation (NDE), an accurate and precise characterization of defects is fundamental. This paper proposes a novel method for characterization of partial detachment of thermal barrier coatings from metallic surfaces ...
Giuseppe Dinardo +3 more
doaj +1 more source
, 1982 An evaluation is made of the suitability of analytical and statistical sampling methods for making uncertainty analyses. The adjoint method is found to be well-suited for obtaining sensitivity coefficients for computer programs involving large numbers of equations and input parameters. For this purpose the Latin Hypercube Sampling method is found to be
openaire +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Extremely Efficient Design of Organic Thin Film Solar Cells via Learning-Based Optimization
Energies, 2017 Design of efficient thin film photovoltaic (PV) cells require optical power absorption to be computed inside a nano-scale structure of photovoltaics, dielectric and plasmonic materials.
Mine Kaya, Shima Hajimirza
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Cost-Benefit Analysis Under Uncertainty [PDF]
In what follows we provide a conceptually correct procedure for determining whether a risky project passes the "potential Pareto improvement" welfare criterion which forms the normative basis of cost-benefit analysis.
David A. Graham
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source