Results 91 to 100 of about 24,503,001 (297)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2022 S.25-42The goal of this chapter is to define different types of uncertainty in technical systems and to provide a unified terminology for this book. Indeed, uncertainty comes in different disguises.
Pfetsch, M.E. +8 more
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
SensorsReal-world rotordynamic systems exhibit inherent uncertainties in manufacturing tolerances, material properties, and operating conditions. This study presents a Monte Carlo simulation approach using MSC Adams View and Adams Insight to investigate the ...
Zdenko Šavrnoch +7 more
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
, 2005 One statement that can confidently be made about any transport project is that the costs and benefits are uncertain. An important question is 'how uncertain'? By analyzing the risk and uncertainty which
Nellthorp, John +2 more
core +1 more source
Short-term wind power prediction and uncertainty analysis based on VDM-TCN and EM-GMM
Frontiers in Energy ResearchDue to the fluctuating and intermittent nature of wind energy, its prediction is uncertain. Hence, this paper suggests a method for predicting wind power in the short term and analyzing uncertainty using the VDM-TCN approach.
Bo Peng +5 more
doaj +1 more source
Sub-Pixel Extraction of Laser Stripe Center Using an Improved Gray-Gravity Method †
Sensors, 2017 Laser stripe center extraction is a key step for the profile measurement of line structured light sensors (LSLS). To accurately obtain the center coordinates at sub-pixel level, an improved gray-gravity method (IGGM) was proposed.
Yuehua Li +3 more
doaj +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source