Results 231 to 240 of about 1,877,236 (302)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

open access: yesAdvanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska   +14 more
wiley   +1 more source

Global Nitrogen Deposition Promotes Carbon Sink Formation in Terrestrial Ecosystems

open access: yesAdvanced Science, EarlyView.
Nitrogen deposition alleviates ecosystem N limitation and enhances carbon sinks. Using 829 observations, we show 36% of deposited N is retained globally (39.15 Tg N yr−1), with distinct NHx and NOy contributions. This retention drives a terrestrial C sink of 0.88 Pg C yr−1 (25.48%), highlighting the importance of pool‐specific C:N stoichiometry ...
Lei Li   +6 more
wiley   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

open access: yesAdvanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang   +21 more
wiley   +1 more source

Editorial: Regulatory science: addressing uncertainties in medicines development, evaluation and use

open access: yesFrontiers in Medicine
Liese Barbier   +3 more
doaj   +1 more source

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

open access: yesAdvanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi   +3 more
wiley   +1 more source

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