Results 61 to 70 of about 1,121,216 (274)
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Dasymetric Modeling and Uncertainty [PDF]
Annals of the Association of American Geographers, 2013 Dasymetric models increase the spatial resolution of population data by incorporating related ancillary data layers. The role of uncertainty in dasymetric modeling has not been fully addressed as of yet. Uncertainty is usually present because most population data are themselves uncertain, and/or the geographic processes that connect population and the ...
Nagle, Nicholas N. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Modeling Latent Variable Uncertainty for Loss-based Learning [PDF]
, 2012 We consider the problem of parameter estimation using weakly supervised datasets, where a training sample consists of the input and a partially specified annotation, which we refer to as the output.
Koller, Daphne +2 more
core +4 more sources
A Convex Reconstruction Model for X-ray Tomographic Imaging with Uncertain Flat-fields [PDF]
, 2017 Classical methods for X-ray computed tomography are based on the assumption that the X-ray source intensity is known, but in practice, the intensity is measured and hence uncertain.
Aggrawal, Hari Om +3 more
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Climate model uncertainty versus conceptual geological uncertainty in hydrological modeling [PDF]
Hydrology and Earth System Sciences, 2015 Abstract. Projections of climate change impact are associated with a cascade of uncertainties including in CO2 emission scenarios, climate models, downscaling and impact models. The relative importance of the individual uncertainty sources is expected to depend on several factors including the quantity that is projected.
T. O. Sonnenborg +2 more
openaire +3 more sources
Uncertainty quantification for kinetic models in socio-economic and life sciences
, 2017 Kinetic equations play a major rule in modeling large systems of interacting particles. Recently the legacy of classical kinetic theory found novel applications in socio-economic and life sciences, where processes characterized by large groups of agents ...
A Chertock +70 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source