Results 71 to 80 of about 25,679,411 (340)

Investment decisions in manufacturing: Assessing the effects of real oil prices and their uncertainty [PDF]

, 2012
We investigate the effects of real oil prices and their uncertainty on the investment decision. Making use of plant-level data, we estimate dynamic, discrete choice models that allow modeling investment inaction, under different assumptions related to ...
Drakos, K, Konstantinou, P
core   +1 more source

Hybrid Neutrosophic Multi-Criteria Decision Model for Guest Selection in Collaborative Tourism Platforms [PDF]

Neutrosophic Sets and Systems
This study presents a hybrid multi-criteria decision-making (MCDM) model applied to the guest selection process in Airbnb-style vacation rentals. The model integrates the PAPRIKA method, Analytic Hierarchy Process (AHP), and Neutrosophic TOPSIS to ...
Vladimir Vega Falcón, Yoarnelys Vasallo Villalonga, Lorenzo Cevallos-Torres   +2 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modeling Latent Variable Uncertainty for Loss-based Learning [PDF]

, 2012
We consider the problem of parameter estimation using weakly supervised datasets, where a training sample consists of the input and a partially specified annotation, which we refer to as the output.
Koller, Daphne, Kumar, M. Pawan, Packer, Ben   +2 more
core   +4 more sources

Dasymetric Modeling and Uncertainty [PDF]

Annals of the Association of American Geographers, 2013
Dasymetric models increase the spatial resolution of population data by incorporating related ancillary data layers. The role of uncertainty in dasymetric modeling has not been fully addressed as of yet. Uncertainty is usually present because most population data are themselves uncertain, and/or the geographic processes that connect population and the ...
Nagle, Nicholas N., Buttenfield, Barbara P., Leyk, Stefan, Spielman, Seth   +3 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Climate model uncertainty versus conceptual geological uncertainty in hydrological modeling [PDF]

Hydrology and Earth System Sciences, 2015
Abstract. Projections of climate change impact are associated with a cascade of uncertainties including in CO2 emission scenarios, climate models, downscaling and impact models. The relative importance of the individual uncertainty sources is expected to depend on several factors including the quantity that is projected.
T. O. Sonnenborg, D. Seifert, J. C. Refsgaard   +2 more
openaire   +3 more sources