Results 91 to 100 of about 110,431 (303)

Robust Ensemble of Computational Techniques for the Detection of Outliers in the Inverse Uncertainty Quantification with Limited Data

, 2023
In the analysis of safety-critical systems, the outputs of the simulation models can diverge substantially from the actual system dynamics. This discrepancy is due to the aleatory (randomness) and epistemic (lack of knowledge) uncertainties affecting the
Pedroni, Nicola
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Present and Future of Model Uncertainty Quantification in Process Systems Engineering

Chemical Engineering Transactions, 2019
This contribution investigates the impact of model uncertainty quantification techniques in different areas of process systems engineering (PSE), namely dynamic optimization, predictive maintenance, soft-sensor systems and risk assessment, using three ...
Francesco Rossi, Linas Mockus, Flavio Manenti, Gintaras Reklaitis   +3 more
doaj   +1 more source

Uncertainty Quantification and Deep Ensembles

CoRR, 2020
Deep Learning methods are known to suffer from calibration issues: they typically produce over-confident estimates. These problems are exacerbated in the low data regime. Although the calibration of probabilistic models is well studied, calibrating extremely over-parametrized models in the low-data regime presents unique challenges.
Rahul Rahaman, Alexandre H. Thiéry
openaire   +3 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Temporal distribution shift in real-world pharmaceutical data: Implications for uncertainty quantification in QSAR models

Artificial Intelligence in the Life Sciences
The estimation of uncertainties associated with predictions from quantitative structure–activity relationship (QSAR) models can accelerate the drug discovery process by identifying promising experiments and allowing an efficient allocation of resources ...
Hannah Rosa Friesacher, Emma Svensson, Susanne Winiwarter, Lewis Mervin, Adam Arany, Ola Engkvist   +5 more
doaj   +1 more source

Neural Network-Based Uncertainty Quantification: A Survey of Methodologies and Applications

IEEE Access, 2018
Uncertainty quantification plays a critical role in the process of decision making and optimization in many fields of science and engineering. The field has gained an overwhelming attention among researchers in recent years resulting in an arsenal of ...
H. M. Dipu Kabir, Abbas Khosravi, Mohammad Anwar Hosen, Saeid Nahavandi   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Observations by evaluating the uncertainty of stress distribution in truss structures based on probabilistic and possibilistic methods

, 2022
Art. 031006, 9 S.Load-bearing mechanical structures like trusses face uncertainty in loading along with uncertainty in stress and strength, which are due to uncertainty in their development, production, and usage.
Platz, Roland, Li, Sushan
core   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source