Results 71 to 80 of about 85,322 (257)

Neural Network-Based Uncertainty Quantification: A Survey of Methodologies and Applications

IEEE Access, 2018
Uncertainty quantification plays a critical role in the process of decision making and optimization in many fields of science and engineering. The field has gained an overwhelming attention among researchers in recent years resulting in an arsenal of ...
H. M. Dipu Kabir, Abbas Khosravi, Mohammad Anwar Hosen, Saeid Nahavandi   +3 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Temporal distribution shift in real-world pharmaceutical data: Implications for uncertainty quantification in QSAR models

Artificial Intelligence in the Life Sciences
The estimation of uncertainties associated with predictions from quantitative structure–activity relationship (QSAR) models can accelerate the drug discovery process by identifying promising experiments and allowing an efficient allocation of resources ...
Hannah Rosa Friesacher, Emma Svensson, Susanne Winiwarter, Lewis Mervin, Adam Arany, Ola Engkvist   +5 more
doaj   +1 more source

Uncertainty Quantification with Generative Models

CoRR, 2019
We develop a generative model-based approach to Bayesian inverse problems, such as image reconstruction from noisy and incomplete images. Our framework addresses two common challenges of Bayesian reconstructions: 1) It makes use of complex, data-driven priors that comprise all available information about the uncorrupted data distribution. 2) It enables
Vanessa Böhm, François Lanusse, Uros Seljak   +2 more
openaire   +2 more sources

Efficient Calculation of Uncertainty Quantification [PDF]

, 2014
We consider Uncertainty Quantification (UQ) by expanding the solution in so-called generalized Polynomial Chaos expansions. In these expansions the solution is decomposed into a series with orthogonal polynomials in which the parameter dependency becomes an argument of the orthogonal polynomial basis functions.
Maten, ter, E.J.W., Pulch, R., Schilders, W.H.A., Janssen, H.H.J.M.   +3 more
openaire   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

An Uncertainty-Aware Visual System for Image Pre-Processing

Journal of Imaging, 2018
Due to image reconstruction process of all image capturing methods, image data is inherently affected by uncertainty. This is caused by the underlying image reconstruction model, that is not capable to map all physical properties in its entirety.
Christina Gillmann, Pablo Arbelaez, Jose Tiberio Hernandez, Hans Hagen, Thomas Wischgoll   +4 more
doaj   +1 more source