Results 91 to 100 of about 252,868 (269)

Improvement of Laser-Induced Breakdown Spectroscopy Quantitative Performance Using Minimizing Signal Uncertainty as Signal Optimization Target: Taking the Ambient Pressure as an Example

Chemosensors
Quantitative analysis performance is considered the Achilles’ heel of laser-induced breakdown spectroscopy. Improving the raw spectral signal is fundamental to achieving accurate quantification. Signal-to-noise ratio enhancement and uncertainty reduction
Kaifan Zhang, Jianxun Ji, Zhitan Liu, Zongyu Hou, Zhe Wang   +4 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Uncertainty quantification works relevant to fission yields and decay data

EPJ Nuclear Sciences & Technologies, 2018
In the present paper, firstly, we review our previous works on uncertainty quantification (UQ) of reactor physics parameters. This consists of (1) development of numerical tools based on the depletion perturbation theory (DPT), (2) linearity of reactor ...
Chiba Go, Nihira Shunsuke
doaj   +1 more source

Challenges and opportunities at the intersection of model reduction and uncertainty quantification

, 2017
Whitepaper submitted to the 2017 DOE ASCR Applied Math MeetingChallenges and opportunities at the intersection of model reduction and uncertainty quantificationDavid A. Barajas-Solano, Panos Stinis, Xiu Yang, Alexandre M. TartakovskyPacific Northwest National LaboratoryAddressing Question 1b.
Barajas-Solano, David, Tartakovsky, Alexandre, Stinis, Panagiotis, Yang, Xiu   +3 more
openaire   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Bio-inspired neutrosophic-enzyme intelligence framework for pediatric dental disease detection using multi-modal clinical data

Scientific Reports
Pediatric oral diseases affect over 60% of children globally, yet current diagnostic approaches lack precision and speed necessary for early intervention.
Hanaa Salem Marie, Mostafa Elbaz, Riham S. Soliman, Mona Elshirbini Hafez, Amira Abdelhafeez Elkhatib   +4 more
doaj   +1 more source

Improved nuclear-structure corrections to the hyperfine splitting of electronic and muonic deuterium

Physics Letters B
We calculate the nuclear-structure correction to the hyperfine splitting in both electronic and muonic deuterium using interactions from chiral effective field theory. We explore the sensitivity to different parameterizations of the nucleon-nucleon force,
Jose Bonilla, Thomas R. Richardson, Sonia Bacca, Chen Ji, Lucas Platter   +4 more
doaj   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source