Results 91 to 100 of about 44,636 (300)

Multi-Fidelity Adaptive Sampling for Surrogate-Based Optimization and Uncertainty Quantification

Aerospace
Surrogate-based algorithms are indispensable in the aerospace engineering field for reducing the computational cost of optimization and uncertainty quantification analyses, particularly those involving computationally intensive solvers.
Andrea Garbo, Jigar Parekh, Tilo Rischmann, Philipp Bekemeyer   +3 more
doaj   +1 more source

Error regions in quantum state tomography: computational complexity caused by geometry of quantum states

New Journal of Physics, 2017
The outcomes of quantum mechanical measurements are inherently random. It is therefore necessary to develop stringent methods for quantifying the degree of statistical uncertainty about the results of quantum experiments.
Daniel Suess, Łukasz Rudnicki, Thiago O maciel, David Gross   +3 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Marginalization of uninteresting distributed parameters in inverse problems – application to diffuse optical tomography

, 2011
With inverse problems there are often several unknown distributed parameters of which only one may be of interest. Since assigning incorrect fixed values to the uninteresting parameters usually leads to a severely erroneous model, one is forced to ...
Simon R. Arridge, Kolehmainen, V, Ville Kolehmainen, Kaipio, Jari, Tarvainen, T, Tanja Tarvainen, Arridge, SR, Jari P. Kaipio   +7 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Resource Allocation for Uncertainty Quantification and Reduction

, 2014
This dissertation explores resource allocation methods for quantification and reduction of prediction uncertainty from computational models, in order to enable risk assessment and decision-making in engineering systems.
Mullins, Joshua Grady
core  

Improvement of Laser-Induced Breakdown Spectroscopy Quantitative Performance Using Minimizing Signal Uncertainty as Signal Optimization Target: Taking the Ambient Pressure as an Example

Chemosensors
Quantitative analysis performance is considered the Achilles’ heel of laser-induced breakdown spectroscopy. Improving the raw spectral signal is fundamental to achieving accurate quantification. Signal-to-noise ratio enhancement and uncertainty reduction
Kaifan Zhang, Jianxun Ji, Zhitan Liu, Zongyu Hou, Zhe Wang   +4 more
doaj   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Uncertainty Quantification and Management in Additive Manufacturing

, 2020
Additive manufacturing (AM) has shown immense potential in several industries. However, significant variability in the product quality currently hinders widespread use of AM.
Nath, Paromita
core