Results 81 to 90 of about 44,636 (300)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

An Algorithmic Comparison of the Hyper-Reduction and the Discrete Empirical Interpolation Method for a Nonlinear Thermal Problem

Mathematical and Computational Applications, 2018
A novel algorithmic discussion of the methodological and numerical differences of competing parametric model reduction techniques for nonlinear problems is presented.
Felix Fritzen, Bernard Haasdonk, David Ryckelynck, Sebastian Schöps   +3 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Quantification of Uncertainty Associated with Soil Sampling and Its Reduction Approaches [PDF]

Journal of Soil and Groundwater Environment, 2013
It is well known that uncertainty associated with soil sampling is bigger than that with analysis. In this research, uncertainties for soil sampling when assessing TPH and BTEX concentration in soils were quantified based on actual field data. It is almost impossible to assess exact contamination of the site regardless how carefully devised for ...
openaire   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Parameter space dimension reduction for forward and inverse uncertainty quantification

, 2018
Scientists and engineers use computer simulations to study relationships between a physical model's input parameters and its output predictions. However, thorough parameter studies---e.g., constructing response surfaces, optimizing, or averaging---are ...
Constantine, Paul
core  

Challenges and opportunities at the intersection of model reduction and uncertainty quantification

, 2017
Whitepaper submitted to the 2017 DOE ASCR Applied Math MeetingChallenges and opportunities at the intersection of model reduction and uncertainty quantificationDavid A. Barajas-Solano, Panos Stinis, Xiu Yang, Alexandre M. TartakovskyPacific Northwest National LaboratoryAddressing Question 1b.
Barajas-Solano, David, Tartakovsky, Alexandre, Stinis, Panagiotis, Yang, Xiu   +3 more
openaire   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Efficient Uncertainty Quantification for a Fast-Spectrum Generation IV Reactor System

, 2008
This research is part of on-going research on the management of uncertainties in simulator predictions for Generation IV systems via optimum experimental design. The focus is on uncertainties originating due to input data.
Elkins, Jason Robert
core  

B-Spline based uncertainty quantification for stochastic analysis

, 2021
The consideration of uncertainties has become inevitable in state-of-the-art science and technology. Research in the field of uncertainty quantification has gained much importance in the last decades. The main focus of scientists is the identification of
Eckert, Christoph
core   +2 more sources