Results 91 to 100 of about 3,467,566 (283)

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016 [PDF]

, 2018
Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations.

core  

Under-5 mortality rates with 95% confidence intervals (CI) in 27 sub-Saharan African countries.

, 2016
Under-5 mortality rates with 95% confidence intervals (CI) in 27 sub-Saharan African countries.
Andre M. N. Renzaho (3219330), Abukari I. Issaka (3269625), Kingsley E. Agho (2742037)   +2 more
core   +1 more source

Levels and differentials in childhood mortality in South Africa, 1977-1998. [PDF]

, 2007
This study uses the 1996 Census and the 1998 Demographic and Health Survey (DHS) to investigate the level of and trend in infant and child mortality and their covariates in South Africa.
Laubscher, Ria, Timaeus, Ian M, Nannan, Nadine, Bradshaw, Debbie   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Substantial and sustained reduction in under-5 mortality, diarrhea, and pneumonia in Oshikhandass, Pakistan: evidence from two longitudinal cohort studies 15 years apart

BMC Public Health, 2019
Background Oshikhandass is a rural village in northern Pakistan where a 1989–1991 verbal autopsy study showed that diarrhea and pneumonia were the top causes of under-5 mortality. Intensive surveillance, active community health education and child health
C. Hansen, B. J. McCormick, S. Azam, K. Ahmed, J. M. Baker, E. Hussain, A. Jahan, A. Jamison, S. Knobler, N. Samji, W. Shah, D. Spiro, E. Thomas, C. Viboud, Z. Rasmussen, Anita Arif Amin Ahmed Faheemullah Saba Azad Wali Israr M Zaidi Khan Jan Beg Wasim Khan Ahmed Rahim Mughal K, A. Zaidi, Arifuzzaman Khan, Ahmed Jan, Faheemullah Beg, Saba Wasim, Azadi Khan, Israr Ahmed, Musa Rahim, Shamsuddin Mughal, Shahinoor Bente Khan, S. Mughal, Bulbul Jahan, M. Mughal, Zeenat Keswani, W. Shah, A. Mukhi, F. Hashmani, Faran Sikandar, S. Durrani, J. Goodwin, K. Hulbert, Arif Hussain, M. Jibran, Asif Hussain, Meherbano, M. Bano, N. Begum, Malika Zadi, Razia Sultana, Z. Begum, I. Bano, Parveen Bano, G. Jan, N. Jabeen, Dil Roz, M. Meri, S. Parveen, N. Bano, Gulab Jan, Zohra Bano, Mobina Bano, Gul Nasreen, Mehtab Bano, Kaniz Fatima, Nazara, Ghazala, Nasima Begum, Alia Rani, M. Lukman Hakeem, Rubina, Sameena, Zevar Jan, Sunaira, R. Jan   +69 more
semanticscholar   +1 more source