Results 121 to 130 of about 22,246,169 (282)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Factors contributing to under-5 child mortality in Nigeria: A narrative review

open access: yesMedicine
Despite repeated efforts by the Nigerian government and the international community, under-5 child mortality remains alarmingly high in Nigeria. This narrative review aims to reassess the key factors contributing to this persistent public health challenge.
David B. Olawade   +6 more
openaire   +2 more sources

Estimate Under-5 Mortality Rate by Household Economic Status

open access: yes, 2020
The slides were presented on May 17th, 2018 for the Professional Update, Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Chao, Fengqing   +4 more
openaire   +1 more source

Levels and trends in child mortality

open access: yes, 2010
The United Nations Inter-agency Group for Child Mortality Estimation (UN-IGME) updates child mortality estimates annually for monitoring progress. This report presents the UN-IGME's latest estimates of under-five, infant and neonatal mortality and ...
World Health Organization   +3 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Individual Welfare Gains from Deferred Life-Annuities under Stochastic Lee-Carter Mortality [PDF]

open access: yes
A deferred annuity typically includes an option-like right for the policyholder. At the end of the deferment period, he may either choose to receive annuity payouts, calculated based on a mortality table agreed to at contract inception, or receive the ...
Thomas Post
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Telemedicine and Pediatric Care in Rural and Remote Areas of Middle-and-Low-Income Countries: Narrative Review

open access: yesJournal of Epidemiology and Global Health
Objectives Caring for children in low- and middle-income countries (LMIC) can be challenging. This review article aims to explore role of telemedicine in supporting pediatric care in LMIC.
Yossef Alnasser   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

The impact of rural-urban migration on under-two mortality in India

open access: yes, 2003
This paper examines the impact of rural-urban migration on under-two mortality in India, using data from the 1992/93 Indian National Family Health Survey.
McDonald, J.W.   +5 more
core   +1 more source

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