Results 131 to 140 of about 4,329,037 (349)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A Novel CPAP Device With an Integrated Oxygen Concentrator for Low Resource Countries: In Vitro Validation and Usability Test in Field

IEEE Open Journal of Engineering in Medicine and Biology
Goal: To develop and validatea novel neonatal non-invasive respiratory support device prototype designed to operate in low-resource settings. Methods: The device integrates a blower-based ventilator and a portable oxygen concentrator.
Sofia Poletto, Emanuela Zannin, Emanuele Ghilotti, Giovanni Putoto, Jerry Ichto, Peter Lochoro, Moses Obizu, Samuel Okori, Matteo Corno, Raffaele L Dellaca   +9 more
doaj   +1 more source

Survey of under 5 year's children injury and accident’s mortality causes in Kerman state-2013 [PDF]

پژوهش‌های سلامت‌محور, 2015
Introduction: One of the most important improvement and health indexes is under 5-year children’s mortality. Recently under 5-year children decreased but it is still more than developing countries.
Mahmood Nekooee Moghadam, MohamaReza Amiresmaili, Rahil Ghorbani, Hossein Shikhani, Zahra Navabi   +4 more
doaj  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Prognostic indicators of early and late death in children admitted to district hospital in Kenya: cohort study [PDF]

, 2003
OBJECTIVES: To identify clinical indicators of immediate, early, and late mortality in children at admission to a sub-Saharan district hospital and to develop prognostic scores. DESIGN: Prospective cohort study.
Berkley, JA, Lowe, BS, Marsh, K, Mohammed, M, Mwangi, I, Newton, CR, Osier, FH, Ross, A, Shebbe, M   +8 more
core   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Operative and nonoperative management for renal trauma. Comparison of outcomes. A systematic review and meta-analysis [PDF]

, 2017
INTRODUCTION: Preservation of kidney and renal function is the goal of nonoperative management (NOM) of renal trauma (RT). The advantages of NOM for minor blunt RT have already been clearly described, but its value for major blunt and penetrating RT is ...
Brachini, Gioia, Cirillo, Bruno, LA TORRE, Marco, Migliori, Emanuele, Mingoli, Andrea, Sapienza, Paolo, Zambon, Martina   +6 more
core   +1 more source

Double burden of under-5 mortality in LMICs

The Lancet Global Health, 2022
Macharia, Peter M, Beňová, Lenka
openaire   +2 more sources

Small area estimation of under-5 mortality in Bangladesh, Cameroon, Chad, Mozambique, Uganda, and Zambia using spatially misaligned data

Population Health Metrics, 2018
BackgroundThe under-5 mortality rate (U5MR) is an important metric of child health and survival. Country-level estimates of U5MR are readily available, but efforts to estimate U5MR subnationally have been limited, in part, due to spatial misalignment of ...
L. Dwyer-Lindgren, Ellen Squires, Stephanie Teeple, G. Ikilezi, D. Allen Roberts, D. Colombara, S. K. Allen, Stanley M Kamande, Nicholas Graetz, A. Flaxman, C. El Bcheraoui, Kristjana H Asbjornsdottir, Gilbert Asiimwe, Ângelo Augusto, Orvalho Augusto, B. Chilundo, C. De Schacht, S. Gimbel, Carol Kamya, Faith Namugaya, F. Masiye, Cremildo Mauieia, Yodé Miangotar, Honoré Mimche, Acácio Sabonete, Haribondhu Sarma, K. Sherr, M. Simuyemba, A. Sinyangwe, J. Uddin, B. Wagenaar, Stephen S. Lim   +31 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source