Results 51 to 60 of about 35,714 (290)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Hasil Belajar IPA Siswa SD di Daerah Tertinggal dengan Penerapan Model Pembelajaran Inkuiri Terbimbing

open access: yesScholaria: Jurnal Pendidikan dan Kebudayaan, 2020
This study aims to determine the effect of the use of guided inquiry methods on students' science learning results at SDI Wae Ratun. This school is one of the schools in underdeveloped regions.
Ricardus Jundu   +2 more
doaj  

The Mezzogiorno and the single European market: complementary or conflicting aims?

open access: yesPSL Quarterly Review, 2013
The Mezzogiorno is the less prosperous region of Italy, located in the south of the country. The aims of an integrated market and potential monetary union in Europe may conflict with the aims of regional development because underdeveloped areas require ...
M. SARCINELLI
doaj   +1 more source

Underdevelopment through Productivity Improvement Measures in an Advanced Region

open access: yesEUROPEAN RESEARCH STUDIES JOURNAL, 2020
Purpose: This paper analyzes how increasing economies of scale, higher productivity, and falling costs in an advanced region can lead to a relative reduction in progressiveness in an economically weaker region. Design/Methodology/Approach: The author uses the core-peripheral model as a basis for this framework.
openaire   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The role of geography in the analysis of industrial development strategies within the spatial organisation of a region

open access: yesBulletin of Geography. Socio-Economic Series, 2014
Through presenting the main axes in this study, it is clear that identifying a precise concept of industrial development is related to a wider idea of development.
Ayad Ayid Wali
doaj   +1 more source

Home - About - Disclaimer - Privacy