Results 41 to 50 of about 359,262 (278)

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song   +12 more
wiley   +1 more source

Environmental performance of rainwater harvesting strategies in Mediterranean buildings [PDF]

open access: yes, 2016
Purpose: The rapid urbanization and the constant expansion of urban areas during the last decades have locally led to increasing water shortage. Rainwater harvesting (RWH) systems have the potential to be an important contributor to urban water self ...
Angrill Toledo, Sara   +5 more
core   +4 more sources

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

open access: yesAdvanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou   +9 more
wiley   +1 more source

A quantitative assessment method for the correlation between rock mass basic quality and Protodyakonov coefficient

open access: yesFrontiers in Earth Science, 2023
With the implementation of the “Belt and Road” initiative, tunnel projects were designed in accordance with Russian design specifications and constructed by Chinese companies in countries along the route.
Zigang Ji   +6 more
doaj   +1 more source

Assessment of static and dynamic stresses horse-shoe tunnel with connecting gallery using finite element method: (as a case study) [PDF]

open access: yes, 2018
This paper illustrates the use of MIDAS GTS NX to investigate the tunnel’s simulation in order to highlight the effect of static and dynamic load on the behaviour of tunnel to compare this response expressed in terms of displacement and stresses ...
Hrubešová, Eva, Mohammed, Jaafar
core   +1 more source

Recent Advances in Decoupling Strategies for Soft Sensors

open access: yesAdvanced Science, EarlyView.
This review provides an overview of recent advances in decoupling strategies for soft sensors. It summarizes single‐modal sensors that are insensitive to stretching, bending, crosstalk, and other environmental interferences, and highlights emerging multimodal decoupling methods enabled by spatiotemporal information and machine learning.
Yangbo Yuan   +4 more
wiley   +1 more source

An innovative method for creating and using nanoparticles for gas extraction from gas hydrates [PDF]

open access: yesE3S Web of Conferences, 2019
The growth of prices for traditional energy sources prompts Ukraine to seek new approaches to solving energy problems. Today, the country has intensified its work in this direction, in particular, legislative support is being developed and improved, and ...
Bondarenko Volodymyr   +3 more
doaj   +1 more source

Technical and economic effect of the selection and operation of cathodic protection installations [PDF]

open access: yes, 2016
Underground metallic structures are now an integral part of any industrial or commercial facility. The length and the number of such objects increases continuously. Are the new line of oil fields, gas pipelines, erection of storage of petroleum products,
Деревнин, Г. С.   +1 more
core  

The analysis of the tunnel with the middle soil-based wall [PDF]

open access: yes, 2016
The methods for analysis of the ferroconcrete construction for a particular case are proposed in the present work. The underground construction is considered and analyzed as a double-drift frame situated on linearly-deformed basis.
Kikava, Temuri R
core   +2 more sources

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

open access: yesAdvanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin   +17 more
wiley   +1 more source

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