Results 131 to 140 of about 1,552,146 (293)
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
ApoE gene therapy: an overview and update [PDF]
, 2005 Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core
Trends in psychotropic-drug-implicated mortality: Psychotropic drugs as a contributing but non-underlying cause of death. [PDF]
Drug Alcohol Depend, 2021 Vuolo M, Frizzell LC, Kelly BC.
europepmc +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Drugs, Alcohol, and Suicide Represent Growing Share of U.S. Mortality [PDF]
, 2017 In this brief, author Shannon Monnat identifies trends in mortality rates from drugs, alcohol, and suicide by race and sex for adults aged 25 to 54, from the years 2000 to 2014. She reports that—nationwide--the mortality rate from deaths involving drugs,
Monnat, Shannon M.
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Revista de Saúde PúblicaAnalisam-se as principais causas de morte neonatal, a confiabilidade da causa básica constante nas declarações de óbito e o impacto dos problemas de confiabilidade na análise de morte prevenível.
Márcia L. Carvalho, Lynn D. Silver
doaj
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Pediatric cancer deaths: curative or palliative? [PDF]
, 2008 Aims: The aims of this study were to review the deaths of Malaysian pediatric oncology patients in order to determine the major causes and the proportion of patients who received palliative care.
Eni, Juraida +3 more
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Mortalidade em idosos por diabetes mellitus como causa básica e associada
Revista de Saúde PúblicaOBJETIVO:Analisar a mortalidade por diabetes mellitus em idosos e a subenumeração do diabetes como causa do óbito de acordo com estatísticas baseadas unicamente em causa básica de óbito.
Cláudia Medina Coeli +5 more
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