Results 121 to 130 of about 653,871 (246)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Under-reporting of HIV and AIDS as an underlying cause of death in South Africa. [PDF]

AIDS
Groenewald P, Glass T, Kallis N, Holmgren C, Nojilana B, Maqungo M, Cheyip M, Morof D, Nannan N, Bradshaw D.   +9 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Taxa de mortalidade por acidentes de trâsito e frota de veículos

Revista de Saúde Pública
OBJETIVO: A taxa de mortalidade específica por acidentes de trânsito de veículos a motor é usualmente utilizada para efeito das políticas de saúde pública.
Samuel Kilsztajn, César Roberto Leite da Silva, Dorivaldo Francisco da Silva, André da Cunha Michelin, Aissa Rendall de Carvalho, Ivan Lopes Bezerra Ferraz   +5 more
doaj  

Data report about course on underlying cause-of-death coding (ICD-10): the case virtual learning environment of the Brazilian health system. [PDF]

Front Digit Health
Doreto AJ, Teixeira AM, Valentim JLRS, Santos JPQ, Pinto TKB, Mendes YMMB, Dias AP, Coutinho KMD, Gonçalves EN, Pinheiro AS, Fernandes F, Batista NAN, Coutinho KD, Valentim RAM.   +13 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Completeness of MCCD and Accuracy of Underlying Cause of Death [PDF]

Proceedings of the Health Science International Conference (HSIC 2017), 2017
Dyah Rachmadani, Titin Wahyuni
openaire   +1 more source

Accuracy of information on the underlying cause of death: An analysis in Colombia during the COVID-19 pandemic in 2021. [PDF]

PLoS One
Chaparro-Narváez P, Manrique Sanchez JA, Berrio-Parra L, Urrego Ricaurte DC, Torres-Rojas LJ, Orjuela Cantor NP, Mora Aguirre CP, Quevedo YR, Suárez C, Castañeda-Orjuela C.   +9 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source